Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.
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DOI：
10.1186/bcr2599
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Hengstler JG
中科院分区：
文献类型：
--
作者：
Cadenas C;Franckenstein D;Schmidt M;Gehrmann M;Hermes M;Geppert B;Schormann W;Maccoux LJ;Schug M;Schumann A;Wilhelm C;Freis E;Ickstadt K;Rahnenführer J;Baumbach JI;Sickmann A;Hengstler JG
这项工作的目的是研究乳腺癌的硫氧还蛋白还原酶1（TXNRD 1）和硫氧还蛋白相互作用蛋白（TXNIP）的预后影响，氧化应激控制的关键球员，目前被评估为可能的治疗靶点。在788例淋巴结阴性乳腺癌患者中分析了TXNRD 1和TXNIP RNA表达与无转移间期（MFI）的相关性，包括3个单独的队列（美因茨、鹿特丹和Transbig）。探索了与多基因和常规临床参数（年龄、pT分期、分级、激素和ERBB 2状态）的相关性。采用多西环素诱导表达致癌基因ERBB 2的MCF-7细胞，研究ERBB 2对TXNRD 1和TXNIP转录的影响。TXNRD 1与联合队列（风险比= 1.955; P < 0.001）以及所有三个单独队列中的MFI恶化相关。相比之下，TXNIP与更好的预后相关（风险比= 0.642; P < 0.001），并且在所有三个亚组中获得了相似的结果。有趣的是，ERBB 2状态阳性肿瘤患者表达更高水平的TXNRD 1。ERBB 2诱导MCF-7细胞不仅使TXNRD 1立即升高，而且使TXNIP显著降低。随着细胞衰老，TXNIP随后上调，伴随着活性氧水平的强烈增加。TXNRD 1和TXNIP与乳腺癌的预后相关，ERBB 2似乎是以预后不利的方式改变氧化还原控制系统的两个因素的平衡的因素之一。
The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets. Analysis of the association of TXNRD1 and TXNIP RNA expression with the metastasis-free interval (MFI) was performed in 788 patients with node-negative breast cancer, consisting of three individual cohorts (Mainz, Rotterdam and Transbig). Correlation with metagenes and conventional clinical parameters (age, pT stage, grading, hormone and ERBB2 status) was explored. MCF-7 cells with a doxycycline-inducible expression of an oncogenic ERBB2 were used to investigate the influence of ERBB2 on TXNRD1 and TXNIP transcription. TXNRD1 was associated with worse MFI in the combined cohort (hazard ratio = 1.955; P < 0.001) as well as in all three individual cohorts. In contrast, TXNIP was associated with better prognosis (hazard ratio = 0.642; P < 0.001) and similar results were obtained in all three subcohorts. Interestingly, patients with ERBB2-status-positive tumors expressed higher levels of TXNRD1. Induction of ERBB2 in MCF-7 cells caused not only an immediate increase in TXNRD1 but also a strong decrease in TXNIP. A subsequent upregulation of TXNIP as cells undergo senescence was accompanied by a strong increase in levels of reactive oxygen species. TXNRD1 and TXNIP are associated with prognosis in breast cancer, and ERBB2 seems to be one of the factors shifting balances of both factors of the redox control system in a prognostic unfavorable manner.
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影响因子：
50.3
作者：
Moody, SE;Perez, D;Chodosh, LA
通讯作者：
Chodosh, LA
DOI：
10.1016/0167-4781(94)90242-9
发表时间：
1994-09-13
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
CHEN, KS;DELUCA, HF
通讯作者：
DELUCA, HF
影响因子：
45.3
作者：
Loi, Sherene;Haibe-Kains, Benjamin;Sotiriou, Christos
通讯作者：
Sotiriou, Christos
影响因子：
11.2
作者：
Bradshaw, TD;Matthews, CS;Stevens, MFG
通讯作者：
Stevens, MFG
DOI：
10.1073/pnas.0800293105
发表时间：
2008-03-11
影响因子：
11.1
作者：
Hui, Simon T. Y.;Andres, Allen M.;Davis, Roger A.
通讯作者：
Davis, Roger A.