Screening for the Early Detection of Ovarian Cancer
Screening for the Early Detection of Ovarian Cancer
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早期发现卵巢癌的筛查
DOI：
10.2217/whe.09.27
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
D. Robertson
中科院分区：
文献类型：
--
作者：
D. Robertson
评价：Menon U、Gentry-Maharaj A、Hallett R等人：多模式超声筛查卵巢癌的敏感性和特异性，以及检测到的癌症的分期分布：英国卵巢癌筛查合作试验（UKCTOCS）的患病率筛查结果柳叶刀肿瘤10，327-340（2009）中所述。我们进行了一项随机对照试验，以评估血清CA 125和卵巢超声作为卵巢癌早期诊断标志物的应用。该试验包括202，638名绝经后妇女，她们在2001年至2005年期间每年接受评估。一个非筛选组和两个筛选组进行了调查。筛查组包括血清CA 125，这是基于变化率算法，加上经阴道超声（在高危妇女）;和卵巢超声组，在临床审查和手术前。联合检测组对所有原发性卵巢癌和输卵管癌的敏感性、特异性和阳性预测值分别为89.4%、99.8%和43.3%，超声组分别为84.9%、98.2%和5.3%，组间特异性差异显著。联合检测为绝经后妇女卵巢癌筛查提供了必要的特异性。
Evaluation of: Menon U, Gentry-Maharaj A, Hallett R et al.: Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol. 10, 327–340 (2009). A randomized, controlled trial was undertaken to assess the use of serum CA125 and ovarian ultrasound as diagnostic markers in the early detection of ovarian cancer. The trial consisted of 202,638 postmenopausal women who were assessed annually between 2001 and 2005. A nonscreen group and two screening groups were investigated. The screening groups included serum CA125, which was based on a rate-of-change algorithm, plus transvaginal ultrasound (in at-risk women); and an ovarian ultrasound group only, prior to clinical review and surgery. The sensitivity, specificity and positive predictive values for all primary ovarian and tubal cancers for the combined test group was 89.4, 99.8 and 43.3%, respectively, and for the ultrasound group 84.9, 98.2 and 5.3%, respectively, with a significant difference in specificity between groups. The combined test provides the requisite specificity for a screening test for ovarian cancer in postmenopausal women.
DOI：
10.1783/147118909788707887
发表时间：
2009-04
影响因子：
--
作者：
U. Menon;A. Gentry-Maharaj;Rachel Hallett;Andy Ryan;M. Burnell;Aarti Sharma;S. Lewis;S. Davies-S.-Davi
通讯作者：
U. Menon;A. Gentry-Maharaj;Rachel Hallett;Andy Ryan;M. Burnell;Aarti Sharma;S. Lewis;S. Davies-S.-Davi
DOI：
10.1067/s0002-9378(03)00579-9
发表时间：
2003-10-01
影响因子：
9.8
作者：
Barnholtz-Sloan, JS;Schwartz, AG;Munkarah, AR
通讯作者：
Munkarah, AR