Biliverdin protects against liver ischemia reperfusion injury in swine.
Biliverdin protects against liver ischemia reperfusion injury in swine.
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DOI：
10.1371/journal.pone.0069972
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Calise F
中科院分区：
文献类型：
--
作者：
Andria B;Bracco A;Attanasio C;Castaldo S;Cerrito MG;Cozzolino S;Di Napoli D;Giovannoni R;Mancini A;Musumeci A;Mezza E;Nasti M;Scuderi V;Staibano S;Lavitrano M;Otterbein LE;Calise F
器官移植中的缺血再灌注损伤（IRI）是一个严重而尚未解决的问题。在IRI期间受到显著损伤的器官，在再灌注后立即功能不太好，并且在后期可能发生排斥时往往会出现更多问题。胆绿素已成为一种有效抑制啮齿动物模型中IRI的药物。由于胆绿素的使用正在被开发为一种潜在的人类治疗方式，我们测试了其对猪肝脏IRI影响的疗效，猪是一种公认的相关临床前动物模型。胆绿素给药导致血清中胆红素快速出现，并通过多种参数（包括尿素和氨清除率、中性粒细胞浸润和组织组织病理学（包括肝细胞死亡））测量，显著抑制了IR诱导的肝功能障碍。总之，我们的研究结果，在一个大的动物模型，提供了强有力的支持，继续评价胆绿素作为一个潜在的治疗在临床环境中的肝移植，也许其他器官。
Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when rejection can occur. Biliverdin has emerged as an agent that potently suppress IRI in rodent models. Since the use of biliverdin is being developed as a potential therapeutic modality for humans, we tested the efficacy for its effects on IRI of the liver in swine, an accepted and relevant pre-clinical animal model. Administration of biliverdin resulted in rapid appearance of bilirubin in the serum and significantly suppressed IRI-induced liver dysfunction as measured by multiple parameters including urea and ammonia clearance, neutrophil infiltration and tissue histopathology including hepatocyte cell death. Taken together, our findings, in a large animal model, provide strong support for the continued evaluation of biliverdin as a potential therapeutic in the clinical setting of transplantation of the liver and perhaps other organs.
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影响因子：
7.3
作者：
Bulmer, A. C.;Coombes, J. S.;Taylor, S. M.
通讯作者：
Taylor, S. M.
影响因子：
13.5
作者：
Fondevila, C;Shen, XD;Bach, FH
通讯作者：
Bach, FH
DOI：
10.1073/pnas.1108571108
发表时间：
2011-11-15
影响因子：
11.1
作者：
Wegiel, Barbara;Gallo, David;Otterbein, Leo E.
通讯作者：
Otterbein, Leo E.
影响因子：
4.8
作者：
Lavitrano, M;Smolenski, RT;Calise, F
通讯作者：
Calise, F
影响因子：
1.2
作者：
Nakai, Miki;Murata, Naomi;Orino, Koichi
通讯作者：
Orino, Koichi