Associations of glycemia and lipid levels in pregnancy with dyslipidemia 10-14 years later: The HAPO follow-up study.
Associations of glycemia and lipid levels in pregnancy with dyslipidemia 10-14 years later: The HAPO follow-up study.
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DOI：
10.1016/j.diabres.2022.109790
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发表时间：
2022-03
影响因子：
5.1
通讯作者：
Scholtens, Denise M.
中科院分区：
文献类型：
--
作者：
Lowe, Lynn P.;Perak, Amanda M.;Kuang, Alan;Lloyd-Jones, Donald M.;Sacks, David A.;Deorochanawong, Chaicharn;Maresh, Michael;Ma, Ronald C.;Lowe, William L., Jr.;Metzger, Boyd E.;Scholtens, Denise M.
研究妊娠血糖与未来血脂异常的关系。我们分析了高血糖和不良妊娠结局随访研究参与者的数据。我们检查了妊娠糖尿病 (GDM)、空腹、75 克负荷后 1 小时和 2 小时血糖 z 评分总和、胰岛素敏感性和妊娠 24-32 周血脂水平与产后 10-14 年血脂异常之间的关系。在 4,693 名女性中，14.3% 患有 GDM。随访时，平均（SD）年龄为41.7（5.7）岁，32.3%的人总胆固醇（TC）≥5.17，27.2%的人HDL胆固醇<1.29，22.4%的人低密度脂蛋白胆固醇（LDL-C）≥3.36，10.9%的人甘油三酯≥1.69 mmol/L，2.9%的人患有2型糖尿病。协变量调整后，妊娠血糖测量值与所有后续血脂异常相关。对妊娠血脂进行额外调整后，GDM 仍与 TC≥5.17 mmol/L（比值比 [95% CI]，1.63 [1.22–2.18]）和 LDL-C ≥3.36 mmol/L (1.63 [1.20–2.22]）相关，即使没有发生 2 型糖尿病（1.55 [1.15–2.10] 和 1.56）分别为[1.13-2.16]）。妊娠期连续血糖测量与所有后续血脂异常显着相关，与妊娠血脂和 2 型糖尿病无关。妊娠血糖与 10-14 年后的血脂异常相关，与妊娠血脂水平无关，并且在没有发生 2 型糖尿病的情况下。 GDM 后的脂质筛查值得特别考虑。
To examine associations of pregnancy glycemia with future dyslipidemia. We analyzed data from Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study participants. We examined associations of gestational diabetes (GDM), sum of fasting, 1-hour, and 2-hour glucose z-scores after 75-g load, insulin sensitivity, and lipid levels at 24–32 weeks’ gestation with dyslipidemia 10–14 years postpartum. Among 4,693 women, 14.3% had GDM. At follow-up, mean (SD) age was 41.7 (5.7) years, 32.3% had total cholesterol (TC)≥5.17, 27.2% had HDL cholesterol<1.29, 22.4% had LDL cholesterol (LDL-C)≥3.36, 10.9% had triglycerides≥1.69 mmol/L, and 2.9% had type 2 diabetes. After covariate adjustment, pregnancy glycemic measures were associated with all follow-up dyslipidemias. After additional adjustment for pregnancy lipids, GDM remained associated with TC≥5.17 mmol/L (odds ratio [95% CI], 1.63 [1.22–2.18]) and LDL-C≥3.36 mmol/L (1.63 [1.20–2.22]), even in the absence of type 2 diabetes development (1.55 [1.15–2.10] and 1.56 [1.13–2.16], respectively). Continuous glycemic measures in pregnancy were significantly associated with all follow-up dyslipidemias, independent of pregnancy lipids and type 2 diabetes. Pregnancy glycemia was associated with dyslipidemia 10–14 years later, independent of pregnancy lipid levels and in the absence of type 2 diabetes development. Lipid screening after GDM deserves special consideration.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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