A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model.
A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model.
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DOI：
10.1186/s13578-018-0226-2
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发表时间：
2018
影响因子：
7.5
通讯作者：
Gong N
中科院分区：
文献类型：
--
作者：
Wang S;Gumpper K;Tan T;Luo X;Guo H;Ming C;Jiang H;Fang J;Du G;Zhu H;Ma J;Chen Z;Gong N
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution. Additionally, WMO-II reduced the number of apoptotic bodies in stored kidneys compared to HTK treated tissue after 48 h of cold storage by reducing expression of Caspase-9, BiP, Chop, and Caspase-12. WMO-II solution reduced serum creatinine levels and serum potassium in kidneys stored for 48 h when compared to HTK perfusion. WMO-II preserves kidney function as evidenced by the reduction in serum creatinine and potassium during graft transplantation. The online version of this article (10.1186/s13578-018-0226-2) contains supplementary material, which is available to authorized users.
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影响因子：
--
作者：
CLEMENS, MG;MCDONAGH, PF;BAUE, AE
通讯作者：
BAUE, AE
DOI：
10.1002/lt.500030106
发表时间：
1997-01-01
期刊：
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
影响因子：
--
作者：
Tojimbara, T;Wicomb, W N;Esquivel, C O
通讯作者：
Esquivel, C O
影响因子：
2.7
作者：
Rauen, Ursula;Kerkweg, Uta;de Groot, Herbert
通讯作者：
de Groot, Herbert
影响因子：
8.8
作者：
Stewart, Z. A.;Lonze, B. E.;Segev, D. L.
通讯作者：
Segev, D. L.
影响因子：
8.8
作者：
Irish, W. D.;Ilsley, J. N.;Brennan, D. C.
通讯作者：
Brennan, D. C.