Epidemiology of SARS-CoV-2 infection and SARS-CoV-2 positive hospital admissions among children in South Africa.
Epidemiology of SARS-CoV-2 infection and SARS-CoV-2 positive hospital admissions among children in South Africa.
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DOI：
10.1111/irv.12916
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发表时间：
2022-01
影响因子：
4.4
通讯作者：
Blumberg, Lucille
中科院分区：
文献类型：
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作者：
Kufa, Tendesayi;Jassat, Waasila;Cohen, Cheryl;Tempia, Stefano;Masha, Maureen;Wolter, Nicole;Walaza, Sibongile;Gottburg, Anne;Govender, Nelesh P.;Hunt, Gillian;Shonhiwa, Andronica Moipone;Ebonwu, Joy;Ntshoe, Genevie;Maruma, Wellington;Bapela, Poncho;Ndhlovu, Nomathamsanqa;Mathema, Hlengani;Modise, Motshabi;Shuping, Liliwe;Manana, Pinky N.;Moore, David;Dangor, Ziyaad;Verwey, Charl;Madhi, Shabir A.;Saloojee, Haroon;Zar, Heather J.;Blumberg, Lucille
我们描述了南非18岁以下儿童中确诊的SARS-CoV-2感染和阳性入院的流行病学和结果，南非是一个中高收入且高度不平等的国家。使用2020年1月28日至9月19日的实验室和医院COVID-19监测数据。检测率的计算方法为检测SARS-CoV-2的人数除以风险人群;检测阳性率的计算方法为阳性检测除以总检测次数。住院病死率（CFR）是根据住院阳性入院人数和在医院死亡且主治医生判断其死亡与SARS-CoV-2相关的结局数据计算的。315，570名18岁以下儿童接受了SARS-CoV-2检测，占所有3，548，738次检测的8.9%，占全国所有儿童的1.6%。在接受检测的儿童中，46137人（14.6%）呈阳性。儿童占哨点医院所有SARS-CoV-2阳性入院人数的2.9%（n = 2007）。在儿童中，47例死亡（2.6%的病死率）。院内死亡与男性相关[校正比值比（aOR）2.18（95%置信区间[CI] 1.08-4.40）] vs女性;年龄<1岁[aOR 4.11（95% CI 1.08-15.54）]，年龄10-14岁[aOR 4.20（95%CI 1.07 -16.44）]，年龄15-17岁[aOR 4.86（95%1.28 -18.51）]与1-4岁年龄组比较;入住公立医院[aOR 5.07（95% 2.01-12.76）] vs私立医院，≥1种基础疾病[aOR 12.09（95% CI 4.19-34.89）] vs无。有基础疾病的儿童发生严重SARS-CoV-2结局的风险更大。10岁以上的儿童、某些省份的儿童和有基础疾病的儿童应考虑增加检测和疫苗接种。
We describe epidemiology and outcomes of confirmed SARS‐CoV‐2 infection and positive admissions among children <18 years in South Africa, an upper‐middle income setting with high inequality. Laboratory and hospital COVID‐19 surveillance data, 28 January ‐ 19 September 2020 was used. Testing rates were calculated as number of tested for SARS‐CoV‐2 divided by population at risk; test positivity rates were calculated as positive tests divided by total number of tests. In‐hospital case fatality ratio (CFR) was calculated based on hospitalized positive admissions with outcome data who died in‐hospital and whose death was judged SARS‐CoV‐2 related by attending physician. 315 570 children aged <18 years were tested for SARS‐CoV‐2; representing 8.9% of all 3 548 738 tests and 1.6% of all children in the country. Of children tested, 46 137 (14.6%) were positive. Children made up 2.9% (n = 2007) of all SARS‐CoV‐2 positive admissions to sentinel hospitals. Among children, 47 died (2.6% case‐fatality). In‐hospital deaths were associated with male sex [adjusted odds ratio (aOR) 2.18 (95% confidence intervals [CI] 1.08–4.40)] vs female; age <1 year [aOR 4.11 (95% CI 1.08–15.54)], age 10–14 years [aOR 4.20 (95% CI1.07–16.44)], age 15–17 years [aOR 4.86 (95% 1.28–18.51)] vs age 1–4 years; admission to a public hospital [aOR 5.07(95% 2.01–12.76)] vs private hospital and ≥1 underlying conditions [aOR 12.09 (95% CI 4.19–34.89)] vs none. Children with underlying conditions were at greater risk of severe SARS‐CoV‐2 outcomes. Children > 10 years, those in certain provinces and those with underlying conditions should be considered for increased testing and vaccination.
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DOI：
10.15585/mmwr.mm6942e1
发表时间：
2020-10-23
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
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作者：
Gold JAW;Rossen LM;Ahmad FB;Sutton P;Li Z;Salvatore PP;Coyle JP;DeCuir J;Baack BN;Durant TM;Dominguez KL;Henley SJ;Annor FB;Fuld J;Dee DL;Bhattarai A;Jackson BR
通讯作者：
Jackson BR
DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
3.9
作者：
Mahmoudi, Shima;Mehdizadeh, Mehrzad;Mamishi, Setareh
通讯作者：
Mamishi, Setareh
影响因子：
2.4
作者：
Liu, Chan;He, Yu;Shi, Yuan
通讯作者：
Shi, Yuan
影响因子：
36.4
作者：
Goetzinger, Florian;Santiago-Garcia, Begona;Tebruegge, Marc
通讯作者：
Tebruegge, Marc