A computational model of acute focal cortical lesions.
A computational model of acute focal cortical lesions.
复制标题
急性局灶性皮质病变的计算模型。
DOI：
10.1161/01.str.28.1.101
复制
发表时间：
1997
期刊：
影响因子：
8.3
通讯作者：
Whitney,C
中科院分区：
文献类型：
--
作者：
Goodall,S;Reggia,JA;Chen,Y;Ruppin,E;Whitney,C
背景和目的确定大脑皮层如何适应突发性局灶性损害对于更好地了解卒中具有重要意义。在这项研究中，我们使用了一个计算模型来验证一个假说，即模拟脑梗塞后皮质地图的重组严重依赖于周围的兴奋性，并确定影响卒中后重建程度的因素。方法先前报道的控制模拟手臂的初级感觉运动皮质的人工神经网络模型受到急性局灶性损伤。结果模拟皮质区周围兴奋性增强的皮质区与皮损区向即刻皮质区的重新映射相关，皮层的反应性随时间增加而增加。相反，当损伤导致活动度降低的周围区出现时，该区域会随着时间的推移而扩大和加强，并丢失周围区图。增加皮质内连接的假设范围会产生更广泛的不活动范围。这些效应与病变大小无关。结论这些模拟结果表明，缺血性卒中后功能性皮质重组是一个两阶段的过程，其中弥漫性兴奋性起着关键作用。
Background and PurposeDetermining how cerebral cortex adapts to sudden focal damage is important for gaining a better understanding of stroke. In this study we used a computational model to examine the hypothesis that cortical map reorganization after a simulated infarct is critically dependent on perilesion excitability and to identify factors that influence the extent of poststroke reorganization.MethodsA previously reported artificial neural network model of primary sensorimotor cortex, controlling a simulated arm, was subjected to acute focal damage. The perilesion excitability and cortical map reorganization were measured over time and compared.ResultsSimulated lesions to cortical regions with increased perilesion excitability were associated with a remapping of the lesioned area into the immediate perilesion cortex, where responsiveness increased with time. In contrast, when lesions caused a perilesion zone of decreased activity to appear, this zone enlarged and intensified with time, with loss of the perilesion map. Increasing the assumed extent of intracortical connections produced a wider perilesion zone of inactivity. These effects were independent of lesion size.ConclusionsThese simulation results suggest that functional cortical reorganization after an ischemic stroke is a two-phase process in which perilesion excitability plays a critical role.
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大脑和认知障碍的神经建模
DOI：
10.1177/107385849800400611
发表时间：
1996
期刊：
The Neuroscientist
影响因子：
--
作者：
W. Lytton;R. Berndt;E. Ruppin
通讯作者：
E. Ruppin
具有横向连接的网络。
DOI：
10.1152/jn.1996.75.1.217
发表时间：
1996
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Xing,J;Gerstein,GL
通讯作者：
Gerstein,GL
谷氨酸介导的局灶性脑缺血损伤：兴奋毒素假说的修订
影响因子：
6.4
作者：
K. Hossmann
通讯作者：
K. Hossmann
皮质地图重组是一个竞争过程
影响因子：
2.9
作者：
G. Sutton;J. Reggia;S. Armentrout;C. L. D'Autrechy
通讯作者：
C. L. D'Autrechy
影响因子：
15.9
作者：
C. Gilbert
通讯作者：
C. Gilbert