Non-nutritive sweeteners: no class effect on the glycemic or appetite responses to ingested glucose
Non-nutritive sweeteners: no class effect on the glycemic or appetite responses to ingested glucose
复制标题
非营养性甜味剂：对摄入葡萄糖的血糖或食欲反应没有类别影响
DOI：
--
复制
发表时间：
2014
影响因子：
4.7
通讯作者：
J. Mclaughlin
中科院分区：
文献类型：
--
作者：
C. Bryant;L. Wasse;N. Astbury;G. Nandra;J. Mclaughlin
人们对非营养性甜味剂是否能在胃肠道中被感知来调节对摄入的碳水化合物的食欲或吸收反应非常感兴趣。我们确定了一组非营养性甜味剂（阿斯巴甜、糖精和安赛蜜）的效果，这些甜味剂的剂量按正常使用时消耗的剂量提供。每一种药物都与葡萄糖结合使用，评估了它们对 10 名健康受试者的血糖反应和食欲的影响。尽管安赛蜜的影响很小，但阿斯巴甜或糖精在任何时间点对口服葡萄糖的血糖反应都没有额外的影响。然而，没有一个对饥饿或饱腹感产生影响。我们的结论是，没有一致的证据表明非营养甜味剂在与饮食相关剂量的葡萄糖一起剧烈食用时，对健康人类受试者的血糖调节具有类效应。然而，安赛蜜可能需要进一步探索。
There is considerable interest in whether non-nutritive sweeteners are sensed in the gastrointestinal tract to modulate appetitive or absorptive responses to ingested carbohydrate. We determined the effect of a panel of non-nutritive sweeteners, aspartame, saccharin and acesulfame-K, delivered in doses that would be consumed in normal usage. Each was given in combination with glucose, assessing their effect on glycemic responses and appetite in 10 healthy human subjects. There was no additional effect of aspartame or saccharin on the blood glucose response to oral glucose at any time point, although acesulfame-K exerted a small effect. However, none had an effect on perceptions of hunger or fullness. We conclude that there is no consistent evidence that non-nutrient sweeteners, when acutely consumed with glucose in dietetically relevant doses, have a class effect in modulating blood glucose in healthy human subjects. However, acesulfame-K may require further exploration.
DOI：
10.3945/ajcn.2008.26792
发表时间：
2009-01
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Mattes RD;Popkin BM
通讯作者：
Popkin BM