Overexpression of hypoxia-inducible factor-1α and vascular endothelial growth factor in sacral giant cell tumors and the correlation with tumor microvessel density.
Overexpression of hypoxia-inducible factor-1α and vascular endothelial growth factor in sacral giant cell tumors and the correlation with tumor microvessel density.
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DOI：
10.3892/etm.2014.1971
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发表时间：
2014-11
影响因子：
2.7
通讯作者：
Zhu D
中科院分区：
文献类型：
--
作者：
Fu S;Bai R;Zhao Z;Zhang Z;Zhang G;Wang Y;Wang Y;Jiang D;Zhu D
Although classified as benign, giant cell tumors of the bone (GCTB) may be aggressive, recur and even metastasize to the lungs. In addition, the pathogenesis and histogenesis remain unclear; thus, the driving factors behind the strong tumor growth capacity of GCTB require investigation. In the present study, the expression levels of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF), which are promoted by hypoxic conditions, were determined in 22 sacral GCTB samples using immunohistochemistry and western blot analysis. Furthermore, CD34 expression was analyzed using these methods. The correlation between HIF-1α or VEGF expression and the tumor microvessel density (MVD) was then determined. The results demonstrated that HIF-1α, VEGF and CD34 were overexpressed in the 22 sacral GCTB specimens, and overexpression of HIF-1α and VEGF correlated with the tumor MVD. Thus, the present study has provided novel indicators for the tumor growth capacity of GCTBs.
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影响因子：
3.3
作者：
Olivera, P;Perez, E;Maldonado, V
通讯作者：
Maldonado, V
DOI：
10.2106/00004623-198769010-00018
发表时间：
1987-01-01
影响因子：
5.3
作者：
CAMPANACCI, M;BALDINI, N;SUDANESE, A
通讯作者：
SUDANESE, A
影响因子：
5.8
作者：
Brahimi-Horn, M. Christiane;Pouyssegur, Jacques
通讯作者：
Pouyssegur, Jacques
影响因子：
9.4
作者：
Licausi, Francesco;Weits, Daan A.;van Dongen, Joost T.
通讯作者：
van Dongen, Joost T.
影响因子：
6.2
作者：
Atkins, GJ;Haynes, DR;Findlay, DM
通讯作者：
Findlay, DM