Quantitative evaluation of the spinal cord compression in patients with cervical spondylotic myelopathy using synthetic MRI.
Quantitative evaluation of the spinal cord compression in patients with cervical spondylotic myelopathy using synthetic MRI.
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DOI：
10.3389/fphys.2023.1140870
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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目的：本研究旨在探讨综合MRI（包括T1、T2和PD值）在判断脊髓型颈椎病（CSM）严重程度中的可行性和诊断价值。 方法：采用3.0T GE型磁共振扫描机，对51例CSM患者和9例健康对照者进行合成MRI扫描。根据MRI分级系统的方法，将受试者的颈椎管狭窄程度分级为0-III级。通过覆盖整个脊髓在最大压迫水平（MCL）手动绘制感兴趣区（ROI），以生成I-III级组的T1 MCL、T2 MCL和PDMCL值。测量Ⅱ级和Ⅲ级MCL处脊髓前后径（AP）和横径（Trans），计算其相对值：rAP = APMCL/AP normal，rTrans = TransMCL/Transnormal。rMIN = rAP/rTrans. 结果如下：T1 MCL值随严重程度的增加而降低（从0级到II级，p < 0.05），而在III级时显著增加。T2 MCL值在0级至II级之间无显著性差异，而在III级与II级相比显著增加（p < 0.05）。PDMCL值在各年级组间差异无统计学意义。Ⅲ级的rMIN显著低于Ⅱ级（p < 0.05）。T2 MCL值与rMIN呈负相关，与rTrans呈正相关。 结论：合成MRI不仅能提供多种对比图像，而且能提供定量标测，是一种可靠、有效的CSM定量诊断方法。
Objectives: This work aimed to investigate the feasibility and diagnostic value of synthetic MRI, including T1, T2 and PD values in determining the severity of cervical spondylotic myelopathy (CSM). Methods: All subjects (51 CSM patients and 9 healthy controls) underwent synthetic MRI scan on a 3.0T GE MR scanner. The cervical canal stenosis degree of subjects was graded 0—III based on the method of a MRI grading system. Regions of interest (ROIs) were manually drawn at the maximal compression level (MCL) by covering the whole spinal cord to generate T1MCL, T2MCL, and PDMCL values in grade I-III groups. Besides, anteroposterior (AP) and transverse (Trans) diameters of the spinal cord at MCL were measured in grade II and grade III groups, and relative values were calculated as follows: rAP = APMCL/APnormal, rTrans = TransMCL/Transnormal. rMIN = rAP/rTrans. Results: T1MCL value showed a decreasing trend with severity of grades (from grade 0 to grade II, p < 0.05), while it increased dramatically at grade III. T2MCL value showed no significant difference among grade groups (from grade 0 to grade II), while it increased dramatically at grade III compared to grade II (p < 0.05). PDMCL value showed no statistical difference among all grade groups. rMIN of grade III was significantly lower than that of grade II (p < 0.05). T2MCL value was negatively correlated with rMIN, whereas positively correlated with rTrans. Conclusion: Synthetic MRI can provide not only multiple contrast images but also quantitative mapping, which is showed promisingly to be a reliable and efficient method in the quantitative diagnosis of CSM.
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DOI：
10.1016/s1529-9430(02)00566-1
发表时间：
2003-01-01
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Edwards, Charles C 2nd;Riew, K Daniel;Vaccaro, Alexander F
通讯作者：
Vaccaro, Alexander F
影响因子：
3.3
作者：
Liu, Sidong;Meng, Tiebao;Qian, Long
通讯作者：
Qian, Long
DOI：
10.1055/s-0028-1100916
发表时间：
2010-08-01
期刊：
Evidence-based spine-care journal
影响因子：
--
作者：
Karpova, Alina;Craciunas, Sorin;Fehlings, Michael G
通讯作者：
Fehlings, Michael G
影响因子：
3.3
作者：
Warnties, J. B. M.;Leinhard, O. Dahlqvist;Lundberg, P.
通讯作者：
Lundberg, P.
影响因子：
2.4
作者：
Zeng, Cheng;Xiong, Jian;Aghdasi, Bayan
通讯作者：
Aghdasi, Bayan