Differences in Neuropathic Pain and Radiological Features Between AQP4-ON, MOG-ON, and IDON.
Differences in Neuropathic Pain and Radiological Features Between AQP4-ON, MOG-ON, and IDON.
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AQP4-ON、MOG-ON 和 IDON 之间神经性疼痛和放射学特征的差异
DOI：
10.3389/fpain.2022.870211
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是探讨不同类型首发脱髓鞘性视神经炎（ON）的疼痛和影像学特征。83例首发水通道蛋白-4 （AQP4）抗体相关的ON （AQP4-ON, n = 28）、髓鞘少突胶质细胞糖蛋白（MOG）抗体相关的ON （MOG-ON, n = 26）和特发性脱髓鞘性视神经炎（IDON, n = 29）患者纳入本回顾性病例对照研究。我们评估了视神经病变的磁共振成像（MRI），急性疼痛与视神经炎的发作和临床特征，这些患者的血清自身抗体水平不同。AQP4-ON患者24例（85.75%）、MOG-ON患者23例（88.5%）、IDON患者24例（82.8%）出现on相关疼痛。MOG-ON主要是眶后疼痛；AQP4-ON和IDON以神经性疼痛为主。此外，AQP4ON患者的疼痛比其他ON患者更严重。MRI显示AQP4-ON双侧受累较IDON多见（26.9%和3.7%）；放射学视神经头肿胀在MOG-ON组比AQP4-ON和IDON组更常见（68.0比23.1比25.9%）。AQP4-ON的视神经鞘MRI病变更为常见（53.8 vs. 16.0 vs. 3.7%）。70例on相关性疼痛患者中，MOG-ON患者眼眶视神经钆增强最为常见（82.4比55.0比33.3%,P = 0.018）， AQP4-ON患者视交叉增强最为常见（40.0比5.9比6.7%,P = 0.015）。仅在MOG-ON患者中观察到神经周围和眶部增强（P < 0.001）。AQP4-ON患者的增强时间长于MOG-ON和IDON患者。疼痛是所有类型脱髓鞘性ON患者的常见症状。AQP4-ON通常与严重的on相关性疼痛和纵向广泛的视神经炎症病变相关。MOG-ON患者以眶内、视周炎症多见，与眼动引起视盘肿胀、眶后疼痛密切相关。
The purpose of this study was to investigate pain and radiological features of different types of first-episode demyelinating optic neuritis (ON). Eighty-three patients presenting with first-episode aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n = 28), myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n = 26) and idiopathic demyelinating optic neuritis (IDON, n = 29) were included in this retrospective case-control study. We assessed optic nerve lesions on magnetic resonance imaging (MRI), acute pain associated with onset of optic neuritis and clinical characteristics of those ON patients with different serum autoantibody status. 24 AQP4-ON patients (85.75%), 23 MOG-ON patients (88.5%) and 24 IDON patients (82.8%) suffered from ON-associated pain. MOG-ON had mostly retro-orbital pain; AQP4-ON and IDON had mostly neuropathic pain. In addition, pain was more severe in AQP4ON patients than in other ON patients. In MRI, bilateral involvement was more common in AQP4-ON than IDON (26.9 and 3.7%); radiological optic nerve head swelling was more common in MOG-ON than in AQP4-ON and IDON (68.0 vs. 23.1 vs. 25.9%). MRI lesion in peri-optic nerve sheath was more common in AQP4-ON (53.8 vs. 16.0 vs. 3.7%). In 70 patients with ON-associated pain, gadolinium enhancement of orbital optic nerve was most common in MOG-ON patients (82.4 vs. 55.0 vs. 33.3%, P = 0.018), and enhancement of optic chiasma was most common in AQP4-ON patients (40.0 vs. 5.9 vs. 6.7%, P = 0.015). Perineural and orbital enhancement was observed only in patients with MOG-ON (P < 0.001). The length of enhancement was longer in AQP4-ON patients than in MOG-ON and IDON patients. Pain is a common symptom in patients with all types of demyelinating ON. AQP4-ON is frequently associated with severe ON-associated pain and longitudinally extensive optic nerve inflammatory lesions. Intra-orbital and peri-optic inflammation were more frequently observed in patients with MOG-ON, which was closely related to optic disc swelling and retro-orbital pain provoked by eye movements.
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影响因子：
9.9
作者：
Cruccu G;Finnerup NB;Jensen TS;Scholz J;Sindou M;Svensson P;Treede RD;Zakrzewska JM;Nurmikko T
通讯作者：
Nurmikko T
DOI：
10.1177/2055217318796684
发表时间：
2018-07
影响因子：
--
作者：
Asseyer S;Schmidt F;Chien C;Scheel M;Ruprecht K;Bellmann-Strobl J;Brandt AU;Paul F
通讯作者：
Paul F
影响因子：
3.4
作者：
Asseyer S;Cooper G;Paul F
通讯作者：
Paul F
影响因子：
2.8
作者：
Robinson, Rachel R.;Dietz, Alina K.;Forsthuber, Thomas G.
通讯作者：
Forsthuber, Thomas G.
影响因子：
5.8
作者：
Ramanathan, Sudarshini;Prelog, Kristina;Dale, Russell C.
通讯作者：
Dale, Russell C.