Epstein‐Barr virus related gastric cancer in Japan: A molecular patho‐epidemiological study
Epstein‐Barr virus related gastric cancer in Japan: A molecular patho‐epidemiological study
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日本 Epstein-Barr 病毒相关胃癌：一项分子病理流行病学研究
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
C. Land
中科院分区：
文献类型：
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作者：
M. Tokunaga;Y. Uemura;T. Tokudome;T. Ishidate;H. Masuda;E. Okazaki;K. Kaneko;S. Naoe;Masafumi Ito;A. Okamura;A. Shimada;E. Sato;C. Land
EB-巴尔病毒（EBV）参与胃癌已被证实为癌细胞中存在EBV基因组和EBV编码的小RNA（EBER），EBV感染癌细胞的单克隆增殖和抗体滴度升高。本研究旨在调查在日本9个胃癌发病率不同的城市中观察到的胃癌中EBV感染的患病率。EBER-1原位杂交应用于1795例观察的1848例癌的石蜡切片，并基于癌细胞中的均匀杂交检测EBV参与。在6.6%的病变和6.7%的病例中检测到爱泼斯坦-巴尔病毒。每个城市的EBV感染率没有显著差异，并且与潜在的胃癌死亡率没有相关性。因此，日本胃癌发病率的地理差异不能用EBV的参与来解释。Epstein巴尔病毒相关胃癌是日本最常见的EBV相关肿瘤之一。EBV的参与在男性中比女性中更频繁，主要是发生在胃的上部和中部的癌症，并且在男性中表现出更多的细胞类型的变化。这些观察结果表明，其他尚未发现的因素可能会调节EBV在胃癌发生中的因果作用。
Epstein‐Barr virus (EBV) involvement in gastric carcinoma has been demonstrated by the presence of EBV genomes and EBV‐encoded small RNA (EBER) in the carcinoma cells, monoclonal proliferation of EBV‐infected carcinoma cells and elevated antibody titers. The present study was conducted to investigate the prevalence of EBV involvement among gastric carcinomas observed in nine Japanese cities with varying gastric cancer rates. In situ hybridization of EBER‐1 was applied to paraffin sections from 1848 carcinomas observed in 1795 cases and EBV involvement was detected based on uniform hybridization in carcinoma cells. Epstein‐Barr virus was detected in 6.6% of lesions and 6.7% of cases. The rate of EBV involvement did not vary significantly for each city and there was no correlation with underlying gastric cancer mortality rates. Thus, geographic variation of gastric cancer rates within Japan cannot be explained in terms of EBV involvement. Epstein‐Barr virus‐related gastric carcinoma is one of the most common EBV‐related tumors in Japan. The involvement of EBV was significantly more frequent among males than among females, mainly for cancers occurring in the upper and middle part of the stomach, and exhibited more variation by cell type among males. These observations suggest that other factors yet to be discovered may modulate the causal role of EBV in gastric carcinogenesis.
影响因子：
158.5
作者：
WEISS, LM;MOVAHED, LA;SKLAR, J
通讯作者：
SKLAR, J
影响因子：
4.8
作者：
Saucedo, Alma Leticia;Flores-Solis, David;del Rio-Portilla, Federico
通讯作者：
del Rio-Portilla, Federico