A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition.
A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition.
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DOI：
10.1097/gme.0b013e3181df4a19
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Bishop JR
中科院分区：
文献类型：
--
作者：
Sundermann EE;Maki PM;Bishop JR
情绪和认知的变化程度作为生殖阶段、月经期、产后和激素治疗的函数存在显著的个体差异。本文综述了雌激素受体α基因（ESR 1）的变异或多态性在多大程度上预测认知和情绪结果。通过PubMed、EMBASE和PsychINFO进行了1995年至2009年11月的文献检索。对25篇手稿进行了综述，总结了ESR 1在心理健康方面的调查。在调查ESR 1与认知相关性的研究中，14项病例对照研究中有11项报告了ESR 1多态性与痴呆风险之间的关联。四项前瞻性队列研究中有三项报告了ESR 1多态性与显著认知能力下降之间的关联。关于特定的ESR 1等位基因是否增加或减少认知功能障碍的风险，病例对照和队列研究之间存在不一致。ESR 1和认知障碍之间的关系往往是特定于女性或由女性驱动的，并限于阿尔茨海默病的风险，而不是其他痴呆症的原因。五项研究中有三项研究检查了与焦虑或抑郁症状相关的ESR 1多态性，发现了显着的关联。ESR 1多态性与儿童期发病的心境障碍和经前焦虑障碍之间也有显著的相关性。ESR 1变体与认知结果之间的密切关系是显而易见的，初步证据表明ESR 1基因在某些情绪结果中发挥作用。对不一致结果的见解将来自未来的研究，包括单倍型分析，特定种族/种族人群的分析和性别分层分析。
There are significant individual differences in the extent to which mood and cognition change as a function of reproductive stage, menstrual phase, postpartum, and hormone therapy. This review explores the extent to which variations or polymorphisms in the estrogen receptor α gene (ESR1) predict cognitive and mood outcomes. A literature search was conducted from 1995 to November 2009 through PubMed, EMBASE, and PsychINFO. Twenty-five manuscripts were reviewed that summarize investigations of ESR1 in mental health. Among studies investigating ESR1 in relation to cognition, 11 of 14 case-control studies reported an association between ESR1 polymorphisms and risk for developing dementia. Three of four prospective cohort studies reported an association between ESR1 polymorphisms and significant cognitive decline. There are inconsistencies between case-control and cohort studies regarding whether specific ESR1 alleles increase or decrease the risk for cognitive dysfunction. The relationships between ESR1 and cognitive impairment tend to be specific to or driven by women and restricted to risk for Alzheimer’s disease rather than other dementia causes. Three of five studies examining ESR1 polymorphisms in relation to anxiety or depressive symptoms found significant associations. Significant associations have also been reported between ESR1 polymorphisms and childhood-onset mood disorder and premenstrual dysphoric disorder. A strong relationship between ESR1 variants and cognitive outcomes is evident and preliminary evidence suggests a role of the ESR1 gene in certain mood outcomes. Insights into the discordant results will come from future studies that include haplotype analyses, analyses within specific ethnic/racial populations, and gender-stratified analyses.
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影响因子：
11
作者：
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