The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?
The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?
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DOI：
10.3390/genes12030345
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发表时间：
2021-02-26
期刊：
影响因子：
3.5
通讯作者：
Schaefer MR
中科院分区：
文献类型：
--
作者：
Schaefer MR
RNA修饰，长期以来被认为是修饰丰富和非编码RNA的分子好奇心，现在已经成为学术和应用研究的焦点。专门的研究工作（epitranscriptomics）旨在通过确定RNA修饰景观和研究建立，解释和调节RNA信息潜力的分子机制来破译潜在的原则，而不仅仅是四种典型核苷酸的组合。这导致在高分辨率映射各种epitranscriptomes和编目异常RNA修饰电路所造成的影响。虽然所获得的见解的范围是复杂和令人兴奋的，但目前大多数表观转录组学似乎都停留在产生数据的过程中，在研究特定的RNA修饰系统时，很少有努力将原因与后果分开。本文讨论了这一领域的各种知识空白，旨在提出一个具体的问题：如何调节酶动态安装和修改RNA修饰？此外，各种技术将突出其开发和使用可能允许识别特定的和上下文相关的监管epitranscriptomic机制。考虑到个体表转录组的复杂性，确定其调控原则将变得至关重要，特别是当旨在出于实验和潜在的治疗目的修改表转录组的特定方面时。
RNA modifications, long considered to be molecular curiosities embellishing just abundant and non-coding RNAs, have now moved into the focus of both academic and applied research. Dedicated research efforts (epitranscriptomics) aim at deciphering the underlying principles by determining RNA modification landscapes and investigating the molecular mechanisms that establish, interpret and modulate the information potential of RNA beyond the combination of four canonical nucleotides. This has resulted in mapping various epitranscriptomes at high resolution and in cataloguing the effects caused by aberrant RNA modification circuitry. While the scope of the obtained insights has been complex and exciting, most of current epitranscriptomics appears to be stuck in the process of producing data, with very few efforts to disentangle cause from consequence when studying a specific RNA modification system. This article discusses various knowledge gaps in this field with the aim to raise one specific question: how are the enzymes regulated that dynamically install and modify RNA modifications? Furthermore, various technologies will be highlighted whose development and use might allow identifying specific and context-dependent regulators of epitranscriptomic mechanisms. Given the complexity of individual epitranscriptomes, determining their regulatory principles will become crucially important, especially when aiming at modifying specific aspects of an epitranscriptome both for experimental and, potentially, therapeutic purposes.
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DOI：
10.1002/wdev.392
发表时间：
2021-01
期刊：
Wiley interdisciplinary reviews. Developmental biology
影响因子：
--
作者：
Bosch JA;Chen CL;Perrimon N
通讯作者：
Perrimon N
影响因子：
6
作者：
Ahmed S;Hossain Z;Uddin M;Taherzadeh G;Sharma A;Shatabda S;Dehzangi A
通讯作者：
Dehzangi A
DOI：
10.1016/j.tem.2015.09.012
发表时间：
2015-12
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Castello A;Hentze MW;Preiss T
通讯作者：
Preiss T
影响因子：
48
作者：
Benhalevy D;Anastasakis DG;Hafner M
通讯作者：
Hafner M
影响因子：
23.9
作者：
Batista, Pedro J.;Molinie, Benoit;Wang, Jinkai;Qu, Kun;Zhang, Jiajing;Li, Lingjie;Bouley, Donna M.;Lujan, Ernesto;Haddad, Bahareh;Daneshvar, Kaveh;Carter, Ava C.;Flynn, Ryan A.;Zhou, Chan;Lim, Kok-Seong;Dedon, Peter;Wernig, Marius;Mullen, Alan C.;Xing, Yi;Giallourakis, Cosmas C.;Chang, Howard Y.
通讯作者：
Chang, Howard Y.