The role of antigen presenting cells in multiple sclerosis.
The role of antigen presenting cells in multiple sclerosis.
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DOI：
10.1016/j.bbadis.2010.07.008
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发表时间：
2011-02
影响因子：
6.2
通讯作者：
Miller, Stephen D.
中科院分区：
文献类型：
--
作者：
Chastain, Emily M. L.;Duncan, D'Anne S.;Rodgers, Jane M.;Miller, Stephen D.
多发性硬化症（MS）是一种中枢神经系统（CNS）的衰弱性T细胞介导的自身免疫性疾病。MS的动物模型，如实验性自身免疫性脑脊髓炎（EAE）和Theiler鼠脑脊髓炎病毒诱导的脱髓鞘疾病（TMEV-IDD），已经阐明了参与这种器官特异性自身免疫性疾病的起始和进展的细胞机制。在CNS内，抗原呈递细胞（APC）如小胶质细胞和星形胶质细胞作为对抗感染或炎症的第一线防御者参与。然而，在慢性炎症期间，它们可以通过分泌炎性因子和/或将髓鞘表位呈递给自身反应性T细胞来参与使自我破坏性环境永久化。树突状细胞（DC）也参与抗原呈递给T细胞，甚至在CNS内。虽然APC本身并不单独负责介导对髓鞘的破坏，但它们是使炎症环境永久化的关键参与者。本文综述了近年来小胶质细胞、树突状细胞和星形胶质细胞在中枢神经系统自身免疫中的作用。
Multiple Sclerosis (MS) is a debilitating T cell-mediated autoimmune disease of the central nervous system (CNS). Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus-Induced demyelinating disease (TMEV-IDD) have given light to cellular mechanisms involved in the initiation and progression of this organ-specific autoimmune disease. Within the CNS, antigen presenting cells (APC) such as microglia and astrocytes participate as first line defenders against infections or inflammation. However, during chronic inflammation they can participate in perpetuating the self-destructive environment by secretion of inflammatory factors and/or presentation of myelin epitopes to autoreactive T cells. Dendritic cells (DC) are also participants in the presentation of antigen to T cells, even within the CNS. While the APCs alone are not solely responsible for mediating the destruction to the myelin sheath, they are critical players in perpetuating the inflammatory milieu. This review will highlight relevant studies which have provided insight to the roles played by microglia, DCs and astrocytes in the context of CNS autoimmunity.
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影响因子：
4.7
作者：
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通讯作者：
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