Role of endothelin-1 in acute lung injury.
Role of endothelin-1 in acute lung injury.
复制标题
DOI：
10.1016/j.trsl.2009.02.007
复制
发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Briva A
中科院分区：
文献类型：
--
作者：
Comellas AP;Briva A
肺泡-毛细血管膜作为屏障，防止肺泡腔中的液体积聚，并限制大溶质的扩散，同时促进有效的气体交换。当这一屏障功能失调时，患者会发生急性肺损伤（ALI），其特征是肺水肿和肺部炎症增加，导致危及生命的气体交换障碍。除了炎性细胞因子的增加，血浆内皮素-1（ET-1）水平也在ALI患者中增加，ET-1是一种主要的内皮源性血管收缩剂。随着患者病情的恢复，ET-1水平下降，这表明ET-1可能不仅是内皮功能障碍的标志物，而且可能在ALI的发病机制中起作用。当肺水肿累积时，肺泡液体清除率（AFC）至关重要，因为不能恢复正常清除率与肺水肿患者的不良预后相关。AFC涉及主动转运机制，其中钠（Na+）从肺泡气隙主动转运，穿过肺泡上皮，进入肺循环，这产生了负责清除肺水肿的渗透梯度。本文综述了ET-1在ALI发生发展中的作用，ET-1不仅作为一种血管收缩分子，而且通过激活内皮ET-B受体和生成抑制AFC。此外，这篇综述强调了药物的治疗作用，如β-肾上腺素能受体激动剂，特别是内皮素受体拮抗剂在急性肺损伤患者。
The alveolar–capillary membrane serves as a barrier that prevents the accumulation of fluid in the alveolar space and restricts the diffusion of large solutes while facilitating an efficient gas exchange. When this barrier becomes dysfunctional, patients develop acute lung injury (ALI), which is characterized by pulmonary edema and increased lung inflammation that leads to a life-threatening impairment of gas exchange. In addition to the increase of inflammatory cytokines, plasma levels of endothelin-1 (ET-1), which is a primarily endothelium-derived vasoconstrictor, are increased in patients with ALI. As patients recover, ET-1 levels decrease, which suggests that ET-1 may not only be a marker of endothelial dysfunction but may have a role in the pathogenesis of ALI. While pulmonary edema accumulates, alveolar fluid clearance (AFC) is of critical importance, as failure to return to normal clearance is associated with poor prognosis in patients with pulmonary edema. AFC involves active transport mechanisms where sodium (Na+) is actively transported from the alveolar airspaces, across the alveolar epithelium, and into the pulmonary circulation, which creates an osmotic gradient that is responsible for the clearance of lung edema. In this article, we review the relevance of ET-1 in the development of ALI, not only as a vasoconstrictor molecule but also by inhibiting AFC via the activation of endothelial ET-B receptors and generation. Furthermore, this review highlights the therapeutic role of drugs such as beta-adrenergic agonists and, in particular, of endothelin receptor antagonists in patients with ALI.
登录
查看更多内容
影响因子：
8.8
作者：
Dada, LA;Sznajder, JI
通讯作者：
Sznajder, JI
影响因子：
20.1
作者：
EFFROS, RM;MASON, GR;HUKKANEN, J
通讯作者：
HUKKANEN, J
影响因子：
2.3
作者：
Berthiaume, Yves;Matthay, Michael A.
通讯作者：
Matthay, Michael A.
DOI：
10.1152/ajprenal.1995.268.3.f455
发表时间：
1995-03-01
期刊：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY
影响因子：
--
作者：
CLAVELL, AL;STINGO, AJ;BURNETT, JC
通讯作者：
BURNETT, JC
影响因子：
5.7
作者：
Berger, Marc Moritz;Rozendal, C. Sjula;Mairbaeurl, Heimo
通讯作者：
Mairbaeurl, Heimo