Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea.
Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea.
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正常儿童和患有阻塞性呼吸暂停的儿童在睡眠期间对吸气阻力负荷的反应。
DOI：
10.1152/jappl.1999.87.4.1448
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lutz,J
中科院分区：
文献类型：
--
作者：
Marcus,CL;Moreira,GA;Bamford,O;Lutz,J
儿童睡眠期间对上呼吸道吸气阻力负荷(IRL)的反应尚不清楚。因此，与对照组相比，我们评估了阻塞性睡眠呼吸暂停综合征(OSAS)儿童在睡眠中对IRL的唤醒反应。阻塞性睡眠呼吸暂停综合征患儿的睡眠负荷高于对照组(23±8cmH2O⋅L−1⋅S；P<；005)。阻塞性睡眠呼吸暂停综合征患者在快速眼动睡眠时的觉醒阈值高于非快速眼动睡眠时的觉醒阈值(P<；0.001)，而正常人在快速眼动睡眠时的觉醒阈值较低(P<；0.005)。在对照组中评估对IRL的呼吸反应。潮气量在IRL为15cmH2O⋅L−1min时即刻(56±17%，P<0.001)和IRL 3min后(67±23%，P<；0.005)均明显减少。占空比增加。我们的结论是，患有OSAS的儿童对IRL的唤醒反应受损。尽管呼吸计时发生了代偿性变化，但正常儿童在睡眠中对IRL的反应是每分钟通气量减少。然而，觉醒发生在气体交换异常之前。
The response to inspiratory resistance loading (IRL) of the upper airway during sleep in children is not known. We, therefore, evaluated the arousal responses to IRL during sleep in children with the obstructive sleep apnea syndrome (OSAS) compared with controls. Children with OSAS aroused at a higher load than did controls (23 ± 8 vs. 15 ± 7 cmH2O ⋅ l−1⋅ s;P< 0.05). Patients with OSAS had higher arousal thresholds during rapid eye movement (REM) vs. non-REM sleep (P< 0.001), whereas normal subjects had lower arousal thresholds during REM (P< 0.005). Ventilatory responses to IRL were evaluated in the controls. There was a marked decrease in tidal volume both immediately (56 ± 17% of baseline at an IRL of 15 cmH2O ⋅ l−1⋅ min;P< 0.001) and after 3 min of IRL (67 ± 23%,P< 0.005). The duty cycle increased. We conclude that children with OSAS have impaired arousal responses to IRL. Despite compensatory changes in respiratory timing, normal children have a decrease in minute ventilation in response to IRL during sleep. However, arousal occurs before gas-exchange abnormalities.
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DOI：
10.1164/ajrccm/148.6_pt_1.1610
发表时间：
1993-12-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
GREENBERG, HE;SCHARF, SM
通讯作者：
SCHARF, SM
骨性鼻咽的放射学参数和腺样体扁桃体大小与儿童睡眠呼吸暂停发作的比较。
DOI：
10.1016/s0165-5876(87)80006-x
发表时间：
1987
影响因子：
1.5
作者：
E. Laurikainen;M. Erkinjuntti;J. Alihanka;H. Rikalainen;J. Suonpää
通讯作者：
J. Suonpää
DOI：
10.1164/ajrccm/146.5_pt_1.1235
发表时间：
1992-11-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
MARCUS, CL;OMLIN, KJ;WARD, SLD
通讯作者：
WARD, SLD
多动儿童睡眠期间的听觉唤醒阈值。
影响因子：
5.6
作者：
K. Busby;R. T. Pivik
通讯作者：
R. T. Pivik
影响因子：
3.7
作者：
BUSBY, KA;MERCIER, L;PIVIK, RT
通讯作者：
PIVIK, RT