Anxiety Sensitivity as a Malleable Mechanistic Target for Prevention Interventions: A Meta-Analysis of the Efficacy of Brief Treatment Interventions.
Anxiety Sensitivity as a Malleable Mechanistic Target for Prevention Interventions: A Meta-Analysis of the Efficacy of Brief Treatment Interventions.
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DOI：
10.1037/cps0000038
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Otto MW
中科院分区：
文献类型：
--
作者：
Fitzgerald HE;Hoyt DL;Kredlow MA;Smits JAJ;Schmidt NB;Edmondson D;Otto MW
焦虑敏感性（AS）是一种跨诊断的危险因素，也是预防相关精神病理学和负面健康行为的潜在治疗目标。我们在 28 项研究（1,998 名受试者）中进行了荟萃分析，评估了对高危样本进行短暂干预以减少 AS 和相关临床/行为结果（例如抑郁、饮酒）的效果。与对照条件相比，AS 针对性干预措施显示出从治疗前到治疗后缓解 AS 的显着中等效应大小 (d = 0.54)，并且从治疗前到短期随访接近较大效应大小 (d = 0.78)。长期随访的效应大小未达到显着性（d = 0.29）。对于临床/行为结果，AS 干预措施在所检查的三个时间点（d = 0.20-0.41）显示出显着的小到中等的效果。我们的研究结果有助于验证 AS 作为预防工作的可修改机制目标。
Anxiety sensitivity (AS) is a transdiagnostic risk factor and potential treatment target for prevention of associated psychopathology and negative health behaviors. We conducted a meta-analysis evaluating the efficacy of brief interventions in at-risk samples for reducing AS and associated clinical/behavioral outcomes (e.g., depression, alcohol use) across 28 studies (1,998 participants). AS targeted interventions, compared to control conditions, evidenced a significant moderate effect size for alleviating AS from pre- to post-treatment (d = 0.54) and approached a large effect size from pre-treatment to short-term follow-up (d = 0.78). The effect size for long-term follow-up did not reach significance (d = 0.29). For clinical/behavioral outcomes, AS interventions demonstrated significant small-to-moderate effect sizes for the three timepoints examined (d’s = 0.20-0.41). Our findings help validate AS as a modifiable mechanistic target for prevention efforts.
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