Systemic inflammation decreases pain threshold in humans in vivo.
Systemic inflammation decreases pain threshold in humans in vivo.
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DOI：
10.1371/journal.pone.0084159
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pickkers P
中科院分区：
文献类型：
--
作者：
de Goeij M;van Eijk LT;Vanelderen P;Wilder-Smith OH;Vissers KC;van der Hoeven JG;Kox M;Scheffer GJ;Pickkers P
痛觉过敏是众所周知的疾病标志。促炎细胞因子被认为是主要原因，但人类数据很少。通过三种定量感觉测试方法评估了人内毒素血症引起的全身炎症期间疼痛阈值的变化。 27 名健康志愿者在静脉注射 2 ng/kg 纯化大肠杆菌内毒素之前和之后 2 小时测量了压痛阈值、电痛阈值和对冷加压试验的耐受性。另外 20 名未接触内毒素血症的受试者作为对照。内毒素血症导致体温和炎症症状评分升高，以及血浆TNF-α、IL-6、IL-10和IL-1RA升高。在内毒素血症期间，压痛阈值和电痛阈值分别降低 20±4% 和 13±3%。在对照组中，压痛阈值仅略有下降（7±3%），而电痛阈值没有发生变化。内毒素治疗的受试者在冷加压测试期间经历更多疼痛，并且能够完成冷加压测试测量的受试者较少，而在对照中，冷加压测试结果没有改变。每种细胞因子的峰值水平和曲线下面积与通过应用的定量感觉测试技术之一测量的疼痛阈值的变化不相关。 总之，这项研究表明，人类施用内毒素引起的全身炎症会导致通过 3 种定量感觉测试技术测量的疼痛阈值降低。目前的工作提供了额外的证据，表明全身炎症伴随着疼痛感知的变化。
Hyperalgesia is a well recognized hallmark of disease. Pro-inflammatory cytokines have been suggested to be mainly responsible, but human data are scarce. Changes in pain threshold during systemic inflammation evoked by human endotoxemia, were evaluated with three quantitative sensory testing methods. Pressure pain thresholds, electrical pain thresholds and tolerance to the cold pressor test were measured before and 2 hours after the intravenous administration of 2 ng/kg purified E. coli endotoxin in 27 healthy volunteers. Another 20 subjects not exposed to endotoxemia served as controls. Endotoxemia led to a rise in body temperature and inflammatory symptom scores and a rise in plasma TNF-α, IL-6, IL-10 and IL-1RA. During endotoxemia, pressure pain thresholds and electrical pain thresholds were reduced with 20±4 % and 13±3 %, respectively. In controls only a minor decrease in pressure pain thresholds (7±3 %) and no change in electrical pain thresholds occurred. Endotoxin-treated subjects experienced more pain during the cold pressor test, and fewer subjects were able to complete the cold pressor test measurement, while in controls the cold pressor test results were not altered. Peak levels and area under curves of each individual cytokine did not correlate to a change in pain threshold measured by one of the applied quantitative sensory testing techniques. In conclusion, this study shows that systemic inflammation elicited by the administration of endotoxin to humans, results in lowering of the pain threshold measured by 3 quantitative sensory testing techniques. The current work provides additional evidence that systemic inflammation is accompanied by changes in pain perception.
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DOI：
10.1186/cc3050
发表时间：
2005-04
期刊：
Critical care (London, England)
影响因子：
--
作者：
van Eijk LT;Pickkers P;Smits P;van den Broek W;Bouw MP;van der Hoeven JG
通讯作者：
van der Hoeven JG
影响因子：
7.6
作者：
Diogenes, A.;Ferraz, C. C. R.;Hargreaves, K. M.
通讯作者：
Hargreaves, K. M.
DOI：
10.1179/096805105x58715
发表时间：
2005-01-01
期刊：
JOURNAL OF ENDOTOXIN RESEARCH
影响因子：
--
作者：
Dorresteijn, MJ;van Eijk, LT;Pickkers, P
通讯作者：
Pickkers, P
影响因子：
2.8
作者：
Oezaktay, A. Cueneyt;Kallakuri, Srinivasu;Weinstein, James N.
通讯作者：
Weinstein, James N.
影响因子：
7.3
作者：
SAFIEHGARABEDIAN, B;POOLE, S;WOOLF, CJ
通讯作者：
WOOLF, CJ