Action of melatonin on squamous cell carcinoma and other tumors of the oral cavity (Review).
Action of melatonin on squamous cell carcinoma and other tumors of the oral cavity (Review).
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DOI：
10.3892/ol.2014.1813
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发表时间：
2014-04
期刊：
影响因子：
2.9
通讯作者：
DE Diego RG
中科院分区：
文献类型：
--
作者：
Cutando A;López-Valverde A;DE Vicente J;Gimenez JL;Carcía IA;DE Diego RG
褪黑激素（MLT; N-乙酰基-5-甲氧基色胺）是一种主要在松果体中合成的激素。MLT已被证明具有多种功能。该激素是一种自由基清除剂，具有免疫调节作用，刺激I型胶原蛋白的增殖和合成，促进骨形成。此外，MLT通过几种生物学机制发挥抑瘤活性，包括抗增殖功能、刺激抗癌免疫、调节癌基因表达以及抗炎、抗氧化和抗血管生成作用。此外，MLT在培养中抑制人类癌细胞生长，先前的临床研究也证实了其体内抗癌特性。关于MLT在肿瘤过程中的潜在机制，包括口腔肿瘤如表皮样癌，对MT 1和2膜受体、MT3和钙调蛋白胞质结合位点以及RZR/ROR家族的核受体所起作用的认识正在增加。据推测，外源性恢复MT 1（MTNR 1A）的表达抑制口腔鳞状细胞癌细胞缺乏受体的表达的生长。MLT的肿瘤抑制功能和MT 1受体在各种肿瘤中的存在表明该受体可能在口腔癌发生中起关键作用。本文就MLT在口腔癌中的临床意义作一综述。
Melatonin (MLT; N-acetyl-5-metoxy-tryptamine) is a hormone that is principally synthesized in the pineal gland. MLT has been shown to exhibit a variety of functions. The hormone, which is a free radical scavenger, plays an immunomodulatory role, stimulates the proliferation and synthesis of type I collagen and promotes bone formation. Moreover, MLT exerts oncostatic activity through several biological mechanisms, including antiproliferative functions, stimulation of anticancer immunity, modulation of oncogene expression and anti-inflammatory, antioxidant and antiangiogenic effects. In addition, MLT inhibits human cancer cell growth in culture, and previous clinical studies have also confirmed its anticancer properties in vivo. With regard to the underlying mechanisms of MLT in tumor processes, including oral cavity tumors such as epidermoid carcinoma, knowledge of the role played by the MT1 and 2 membrane receptors, MT3 and the calmodulin cytosolic binding sites, as well as the nuclear receptors of the RZR/ROR family, is increasing. It has been hypothesized that exogenous restoration of MT1 (MTNR1A) expression inhibits the growth of oral squamous cell carcinoma cells lacking the expression of the receptor. The tumor suppressing functions of MLT and the presence of the MT1 receptor in various tumors indicate that the receptor may play a pivotal role in oral carcinogenesis. The current review discusses the clinical significance of MLT in oral cancer.
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影响因子：
10.3
作者：
Boutin, Jean A.;Marcheteau, Estelle;Ferry, Gilles
通讯作者：
Ferry, Gilles
DOI：
10.1046/j.1432-1033.2003.03430.x
发表时间：
2003-03-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Macías, M;Escames, G;Acuña-Castroviejo, D
通讯作者：
Acuña-Castroviejo, D
影响因子：
11.4
作者：
Levoye, Angelique;Dam, Julie;Jockers, Ralf
通讯作者：
Jockers, Ralf
影响因子：
10.3
作者：
LAAKSO, ML;PORKKAHEISKANEN, T;JOHANSSON, G
通讯作者：
JOHANSSON, G
影响因子：
10.3
作者：
Jung-Hynes B;Reiter RJ;Ahmad N
通讯作者：
Ahmad N