Lipid metabolism and its implication in mycobacteria-host interaction.

Lipid metabolism and its implication in mycobacteria-host interaction.
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DOI:
10.1016/j.mib.2017.11.020
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发表时间:
2018-03
影响因子:
5.4
通讯作者:
Gramajo H
Gramajo H
中科院分区:
生物学2区
文献类型:
--
作者:
Gago G;Diacovich L;Gramajo H

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结核分枝杆菌(Mtb)细胞壁中的复杂脂质作为主要的效应分子与宿主相互作用,调节宿主的代谢,刺激免疫反应,进而影响宿主细胞和细菌的生理。宿主的脂类也是病原体的营养来源,通过调节脂类平衡来决定感染的命运。尽管新的感染技术和实验模型在很大程度上有助于在脂质水平上理解宿主-病原体相互作用的不同方面,但这种相互作用在结核分枝杆菌脂质调节中的影响仍然处于初级阶段,主要是因为这一研究领域的背景知识较少。
The complex lipids present in the cell wall of Mycobacterium tuberculosis (Mtb) act as major effector molecules that actively interact with the host, modulating its metabolism and stimulating the immune response, which in turn affects the physiology of both, the host cell and the bacilli. Lipids from the host are also nutrient sources for the pathogen and define the fate of the infection by modulating lipid homeostasis. Although new technologies and experimental models of infection have greatly helped understanding the different aspects of the host-pathogen interactions at the lipid level, the impact of this interaction in the Mtb lipid regulation is still incipient, mainly because of the low background knowledge in this area of research.
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