The emerging roles of exosomal circRNAs in diseases.
The emerging roles of exosomal circRNAs in diseases.
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外泌体环状rna在疾病中的新作用。
DOI：
10.1007/s12094-020-02485-6
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Guo X;Tan W;Wang C
外泌体是一种纳米级的磷脂双层囊泡，富含特定的蛋白质、核酸和脂质，它们参与了机体的多种生物学过程，包括生理学和病理学。CircRNA（circular RNA）是一类具有组织发育特异性表达模式的单链封闭分子，其在各种疾病中具有重要的调节功能。外泌体中的非编码RNA（如microRNA和长非编码RNA）也被证明在人类中发挥重要的调节作用。然而，很少有研究关注外泌体circRNA。最近，CircRNA已被鉴定为在外泌体中富集并稳定表达。本文综述了exosomes和circRNA的生物起源和生物学功能，并进一步揭示了exosomes来源的circRNA在不同疾病中的潜在作用。此外，我们建议将其用作疾病，特别是癌症的诊断标志物和治疗标点。
Exosomes, the nanoscale phospholipid bilayer vesicles, enriched in selected proteins, nucleic acids and lipids, which they participated in a variety of biological processes in the body, including physiology and pathology. CircRNAs (circular RNAs) are a class of single-stranded closed molecules with tissue development specific expression patterns that have crucial regulatory functions in various diseases. Non-coding RNAs (such as microRNAs and long non‑coding RNAs) in exosomes have also been shown to play an important regulatory role in humans. However, little research has focused on exosomal circRNAs. Recently, CircRNAs have been identified to be enriched and stably expressed in exosomes. In this review, we summarize the biogenesis and biological functions of exosomes and circRNA, and further revealed the potential role of exosome-derived circRNA in different diseases. Besides, we propose its use as a diagnostic marker and therapeutic punctuation for diseases, especially in cancer.
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