Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
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DOI：
10.3389/fcell.2020.615131
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发表时间：
2020
影响因子：
5.5
通讯作者：
Staal FJT
中科院分区：
文献类型：
--
作者：
Jridi I;Canté-Barrett K;Pike-Overzet K;Staal FJT
WNT蛋白包括一个高度保守的糖蛋白大家族，以其在发育、细胞命运指定、组织再生和组织内稳态中的作用而闻名。Wnt信号的异常与发育缺陷、恶性转化、癌症的发生以及炎症有关。越来越多的研究证据表明，Wnt信号的异常激活参与了慢性炎症性疾病的发病机制，如神经炎、癌症介导性炎症和代谢性炎症性疾病。最近的发现强调了Wnt在调节炎性细胞因子的产生中的作用，如核因子-kB信号，在天然防御机制中以及在天然免疫和获得性免疫之间的桥梁作用。这引发了基于Wnt调节的炎症性疾病治疗新方法的发展。在这里，我们总结了Wnt通路在炎症性疾病中的作用和功能，并重点介绍了Wnt信号作为潜在的炎症主要调节因子，可以作为治疗靶点。
Wnt proteins comprise a large family of highly conserved glycoproteins known for their role in development, cell fate specification, tissue regeneration, and tissue homeostasis. Aberrant Wnt signaling is linked to developmental defects, malignant transformation, and carcinogenesis as well as to inflammation. Mounting evidence from recent research suggests that a dysregulated activation of Wnt signaling is involved in the pathogenesis of chronic inflammatory diseases, such as neuroinflammation, cancer-mediated inflammation, and metabolic inflammatory diseases. Recent findings highlight the role of Wnt in the modulation of inflammatory cytokine production, such as NF-kB signaling and in innate defense mechanisms as well as in the bridging of innate and adaptive immunity. This sparked the development of novel therapeutic treatments against inflammatory diseases based on Wnt modulation. Here, we summarize the role and function of the Wnt pathway in inflammatory diseases and focus on Wnt signaling as underlying master regulator of inflammation that can be therapeutically targeted.
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DOI：
10.1097/ta.0000000000000566
发表时间：
2015-04
期刊：
The journal of trauma and acute care surgery
影响因子：
--
作者：
Kuncewitch M;Yang WL;Jacob A;Khader A;Giangola M;Nicastro J;Coppa GF;Wang P
通讯作者：
Wang P
影响因子：
82.9
作者：
Cao Z;Lis R;Ginsberg M;Chavez D;Shido K;Rabbany SY;Fong GH;Sakmar TP;Rafii S;Ding BS
通讯作者：
Ding BS
影响因子：
4.8
作者：
Bourhis, Eric;Tam, Christine;Hannoush, Rami N.
通讯作者：
Hannoush, Rami N.
影响因子：
56.9
作者：
Boutros, M;Mihaly, J;Mlodzik, M
通讯作者：
Mlodzik, M
影响因子：
11.2
作者：
Du, Qiang;Zhang, Xinglu;Geller, David A.
通讯作者：
Geller, David A.