Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging.
Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging.
复制标题
胰岛素与阿尔茨海默氏病和衰老的认知下降和萎缩有不同的关系。
DOI：
10.1016/j.bbadis.2011.06.011
复制
发表时间：
2012-03
影响因子：
6.2
通讯作者：
Swerdlow, Russell H.
中科院分区：
文献类型：
--
作者：
Burns, Jeffrey M.;Honea, Robyn A.;Vidoni, Eric D.;Hutfles, Lewis J.;Brooks, William M.;Swerdlow, Russell H.
我们评估了早期阿尔茨海默病（AD，n=48）和非痴呆对照（n=61）中胰岛素抵抗与认知能力下降和脑萎缩的关系。在基线时进行静脉葡萄糖耐量试验，以确定胰岛素曲线下面积（AUC）。在基线和2年随访时进行了一系列标准认知任务和MRI检查。在非痴呆对照组中，较高的基线胰岛素AUC与2年整体认知能力下降相关（β =-0.36，p=0.005）。然而，在早期AD中，较高的胰岛素AUC与整体认知能力下降较少（β =0.26，p=0.06）、整体脑萎缩较慢（β =0.40，p=0.01）以及双侧大脑皮层和扣带皮层局部萎缩较少相关。虽然胰岛素抵抗与非痴呆老年人的认知能力下降有关，但较高的外周胰岛素可能具有AD特异性益处，或者胰岛素信号可能受到AD相关全身生理变化的影响。
We assessed the relationship of insulin resistance with cognitive decline and brain atrophy over two years in early Alzheimer’s disease (AD, n=48) and nondemented controls (n=61). Intravenous glucose tolerance tests were conducted at baseline to determine insulin area-under-the-curve (AUC). A standard battery of cognitive tasks and MRI were conducted at baseline and 2-year follow-up. In nondemented controls, higher baseline insulin AUC was associated with 2-year decline in global cognitive performance (beta=−0.36, p=0.005). In early AD, however, higher insulin AUC was associated with less decline in global cognitive performance (beta=0.26, p=0.06), slower global brain atrophy (beta=0.40, p=0.01) and less regional atrophy in the bilateral hippocampi and cingulate cortices. While insulin resistance is associated with cognitive decline in nondemented aging, higher peripheral insulin may have AD-specific benefits or insulin signaling may be affected by systemic physiologic changes associated with AD.
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影响因子：
2.8
作者：
ARAKI, Y;NOMURA, M;NAKAMURA, H
通讯作者：
NAKAMURA, H
DOI：
10.1093/gerona/60.4.471
发表时间：
2005-04-01
影响因子：
5.1
作者：
Beeri, MS;Silverman, JM;Haroutunian, V
通讯作者：
Haroutunian, V
DOI：
10.1111/j.1749-6632.2000.tb06371.x
发表时间：
2000-01-01
期刊：
VASCULAR FACTORS IN ALZHEIMER'S DISEASE
影响因子：
--
作者：
Craft, S;Asthana, S;Plymate, S
通讯作者：
Plymate, S
影响因子：
7.7
作者：
Janson, J;Laedtke, T;Butler, PC
通讯作者：
Butler, PC
影响因子：
--
作者：
Burns, JM;Church, JA;Buckner, RL
通讯作者：
Buckner, RL