Association of cardiotrophin-like cytokine factor 1 levels in peripheral blood mononuclear cells with bone mineral density and osteoporosis in postmenopausal women.
Association of cardiotrophin-like cytokine factor 1 levels in peripheral blood mononuclear cells with bone mineral density and osteoporosis in postmenopausal women.
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绝经后女性外周血单核细胞中心肌营养素样细胞因子因子 1 水平与骨密度和骨质疏松症的关系
DOI：
10.1186/s12891-020-03924-9
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发表时间：
2021-01-11
影响因子：
2.3
通讯作者：
Ge J
中科院分区：
文献类型：
--
作者：
Chen X;Li J;Ye Y;Huang J;Xie L;Chen J;Li S;Chen S;Ge J
研究背景近年来的研究表明，心肌营养素样细胞因子1（CLCF 1）可能是骨稳态的重要调节因子。此外，全基因芯片分析表明，CLCF 1在外周血单个核细胞（PBMC）的表达水平下调绝经后妇女骨质疏松症。本研究旨在评估CLCF 1在PBMC中的表达水平是否可以反映骨量丢失的严重程度和相关的骨折risk.MethodsIn所有，360绝经后妇女，年龄在50至80岁，包括在研究中。结果根据骨健康状况，将27例（7.5%）、165例（45.83%）和168例（46.67%）被调查者分为正常组、骨量减少组和骨质疏松组。正常组和骨量减少组的CLCF 1蛋白水平均高于骨质疏松组。而CLCF 1 mRNA水平与全股骨骨密度正相关（r= 0.169，p = 0.011）和腰椎（r= 0.176，p = 0.001），蛋白水平与腰椎骨密度呈正相关股骨颈（r= 0.236，p = 0.001）、大转子（r = 0.228，p = 0.001）和Ward三角（r= 0.149，p = 0.036）。mRNA和蛋白水平均与骨质疏松的发生呈负相关（分别为r=-0.085，p = 0.011和r =-0.173，p = 0.014）。CLCF 1蛋白水平和骨折风险之间的关联是不显着调整后的BMD.ConclusionsTo我们所知，这是第一个临床研究表明，绝经后妇女的PBMC中的CLCF 1表达水平可以反映骨量或骨量丢失的严重程度。
BackgroundRecent research has suggested that cardiotrophin-like cytokine factor 1 (CLCF1) may be an important regulator of bone homeostasis. Furthermore, a whole gene chip analysis suggested that the expression levels of CLCF1 in the peripheral blood mononuclear cells (PBMCs) were downregulated in postmenopausal women with osteoporosis. This study aimed to assess whether the expression levels of CLCF1 in PBMCs can reflect the severity of bone mass loss and the related fracture risk.MethodsIn all, 360 postmenopausal women, aged 50 to 80 years, were included in the study. A survey to evaluate the participants’ health status, measurement of bone mineral density (BMD), routine blood test, and CLCF1 expression level test were performed.ResultsBased on the participants’ bone health, 27 (7.5%), 165 (45.83%), and 168 (46.67%) participants were divided into the normal, osteopenia, and osteoporosis groups, respectively. CLCF1 protein levels in the normal and osteopenia groups were higher than those in the osteoporosis group. While theCLCF1mRNA level was positively associated with the BMD of total femur (r= 0.169,p= 0.011) and lumbar spine (r= 0.176,p= 0.001), the protein level was positively associated with the BMD of the lumbar spine (r= 0.261,p< 0.001), femoral neck (r= 0.236,p= 0.001), greater trochanter (r= 0.228,p= 0.001), and Ward’s triangle (r= 0.149,p= 0.036). Both the mRNA and protein levels were negatively associated with osteoporosis development (r= − 0.085,p= 0.011 andr= − 0.173,p= 0.014, respectively). The association between CLCF1 protein level and fracture risk was not significant after adjusting for BMD.ConclusionsTo our knowledge, this is the first clinical study to show that CLCF1 expression levels in the PBMCs of postmenopausal women can reflect the amount of bone mass or the severity of bone mass loss.
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