Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort.
Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort.
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DOI：
10.1155/2021/5544198
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发表时间：
2021
影响因子：
1.5
通讯作者：
Jalil F
中科院分区：
文献类型：
--
作者：
Ali Y;Khan S;Chen Y;Farooqi N;Islam ZU;Akhtar M;Aamir;Aman A;Shah AA;Jamal M;Jalil F
类风湿性关节炎（RA）是一种复杂的疾病，其发病和严重程度与遗传和环境因素有关。不同的全基因组关联和候选基因研究已经显示了几个遗传变异在多个基因座/基因中的作用，这些基因座/基因具有种族和地理变异。本研究旨在检测巴基斯坦队列中AFF 3基因的单核苷酸多态性（SNP）rs 10865035与类风湿性关节炎（RA）遗传背景的相关性。共703人，其中包括409例RA患者和294名健康对照，使用TaqMan检测和三引物ARMS-PCR（扩增难治性突变系统-聚合酶链反应）方法进行基因分型。rs 10865035与RA的关联使用不同的模型进行统计学确定。有趣的是，除了纯合隐性模型（G/G vs. A/G + A/A）（OR = 1.693（1.06-2.648）; P = 0.025），所有其他模型，其中包括共显性（χ2 = 5.169; P = 0.075），纯合子显性（A/A vs. G/G + A/G）（OR = 0.867（0.636-1.187）; P = 0.41），杂合子（A/G vs. A/A + GG）（OR = 0.491（0.667-1.215）; P = 0.49）和加性模型（OR = 0.826（0.665-1.027）; P = 0.08）显示病例组和对照组的基因型分布差异无统计学意义。这些研究结果表明，AFF 3基因（rs 10865035）在巴基斯坦人群中RA的发病中没有显着作用。
Rheumatoid arthritis (RA) is one of the complex diseases with the involvement of the genetic as well as environmental factors in its onset and severity. Different genome-wide association and candidate gene studies have shown the role of several genetic variants in multiple loci/genes with ethnical and geographical variations. This study was designed to detect the association of a single-nucleotide polymorphism (SNP) rs10865035 in the AFF3 gene with the genetic background of rheumatoid arthritis (RA) in the Pakistani cohort. A total of 703 individuals, including 409 RA patients and 294 healthy controls, were genotyped using TaqMan assay and Tri primer ARMS-PCR (amplification-refractory mutation system-polymerase chain reaction) methods. The association of rs10865035 with the RA was statistically determined using different models. Interestingly, besides the homozygous recessive model (G/G vs. A/G + A/A) (OR = 1.693(1.06–2.648); P = 0.025), all other models, which included the codominant (χ2 = 5.169; P = 0.075), homozygous dominant (A/A vs. G/G + A/G) (OR = 0.867 (0.636–1.187); P = 0.41), heterozygous (A/G vs. A/A + GG) (OR = 0.491 (0.667–1.215); P = 0.49), and additive model (OR = 0.826 (0.665–1.027); P = 0.08) showed insignificant distribution of the genotypes among the cases and controls. These findings suggest that the AFF3 gene (rs10865035) has no significant role in the onset of RA in the Pakistani population.
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影响因子：
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作者：
Freudenberg, Jan;Lee, Hye-Soon;Bae, Sang-Cheol
通讯作者：
Bae, Sang-Cheol
影响因子：
4.9
作者：
Pierer, Matthias;Kaltenhauser, Sylke;Arnold, Sybille;Wahle, Matthias;Baerwald, Christoph;Hantzschel, Holm;Wagner, Ulf
通讯作者：
Wagner, Ulf
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通讯作者：
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作者：
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通讯作者：
Hayashi, Y
影响因子：
3.5
作者：
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通讯作者：
Worthington J