Targeting antioxidant and antithrombotic biotherapeutics to endothelium.
Targeting antioxidant and antithrombotic biotherapeutics to endothelium.
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DOI：
10.1055/s-0030-1253455
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发表时间：
2010-04
影响因子：
5.7
通讯作者：
Muzykantov VR
中科院分区：
文献类型：
--
作者：
Carnemolla R;Shuvaev VV;Muzykantov VR
The endothelium is one of the key targets for pharmacological interventions in oxidative stress and thrombosis, two conditions that are notoriously difficult to treat due to limited efficacy and precision of action of current drugs. Design of molecular and nano-devices that deliver potent antioxidant and antithrombotic therapeutic enzymes to the endothelium holds promise to improve the potency, localization, timing, specificity, safety, and mechanistic precision of these interventions. In particular, cell adhesion molecules expressed on the surface of resting and pathologically altered endothelial cells can be used for drug delivery to the endothelial surface (preferable for thrombolytics) and into intracellular compartments (preferable for antioxidants). Drug delivery platforms including protein conjugates, recombinant fusion constructs, and stealth polymer carriers designed to target these drugs to endothelium are reviewed in this article.
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1997-09-01
影响因子：
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