Mortality from coronavirus disease 2019 (Covid-19) in patients with schizophrenia: A systematic review, meta-analysis and meta-regression.
Mortality from coronavirus disease 2019 (Covid-19) in patients with schizophrenia: A systematic review, meta-analysis and meta-regression.
复制标题
DOI：
10.1016/j.genhosppsych.2022.01.010
复制
发表时间：
2022-03
影响因子：
7
通讯作者：
Hariyanto TI
中科院分区：
文献类型：
--
作者：
Pardamean E;Roan W;Iskandar KTA;Prayangga R;Hariyanto TI
精神分裂症与患者的生活质量差、残疾和住院有关。截至目前，强调精神分裂症与冠状病毒疾病（Covid-19）结果之间关联的证据仍不清楚。这项研究试图分析既存精神分裂症患者是否有更高的Covid-19死亡风险。使用特定关键词，我们全面检索了PubMed、Scopus、奥维德和科克伦图书馆资源，直至2021年11月15日。收集了所有已发表的关于精神分裂症和新冠肺炎的研究。我们使用Review Manager 5.4和Comprehensive Meta-Analysis 3软件进行统计分析。共有10项研究纳入了263，207名Covid-19患者。对收集到的数据进行评估，发现精神分裂症与新冠肺炎死亡率增加之间存在关联（RR 2.22; 95%CI：1.54-3.20，p < 0.00001，I2 = 82%随机效应模型）。精神分裂症患者因新冠肺炎死亡的风险增加受到年龄较大（p = 0.0004）和吸烟（p = 0.0048）的显著影响。这项研究提出，既存精神分裂症患者有发生COVID-19死亡率较高的风险。精神分裂症患者需要特别关注，应优先接种SARS-CoV-2疫苗。注册详情：CRD 42021293997。
Schizophrenia has been associated with patients' poor quality of life, disability, and hospitalization. As of today, evidence that highlights the association between schizophrenia and coronavirus disease (Covid-19) outcomes remains unclear. This study sought to analyze whether patients with pre-existing schizophrenia are at higher risk for Covid-19 mortality. Using specific keywords, we comprehensively searched PubMed, Scopus, OVID, and Cochrane Library sources until November 15th, 2021. All published studies on schizophrenia and Covid-19 were collected. We used Review Manager 5.4 and Comprehensive Meta-Analysis 3 software to conduct statistical analysis. There were 10 studies with 263,207 Covid-19 patients included in the analysis. Evaluation of the data gathered yielded an association between schizophrenia and increased mortality from Covid-19 (RR 2.22; 95%CI: 1.54–3.20, p < 0.00001, I2 = 82% random-effect model). The increased risk of developing mortality from Covid-19 in patients with schizophrenia was significantly influenced by older age (p = 0.0004) and smoking (p = 0.0048). This study proposes that patients with pre-existing schizophrenia are at risk of developing higher Covid-19 mortality. Patients with schizophrenia need special attention and should be prioritized to receive the SARS-CoV-2 vaccine. Registration details: CRD42021293997.
登录
查看更多内容
影响因子：
6.6
作者：
Fond G;Pauly V;Leone M;Llorca PM;Orleans V;Loundou A;Lancon C;Auquier P;Baumstarck K;Boyer L
通讯作者：
Boyer L
DOI：
10.1016/j.ajem.2020.12.076
发表时间：
2021-03
期刊：
The American journal of emergency medicine
影响因子：
--
作者：
Hariyanto TI;Japar KV;Kwenandar F;Damay V;Siregar JI;Lugito NPH;Tjiang MM;Kurniawan A
通讯作者：
Kurniawan A
影响因子：
10.5
作者：
Jeon, Ha-Lim;Kwon, Jun Soo;Shin, Ju-Young
通讯作者：
Shin, Ju-Young
影响因子：
12.7
作者：
Hariyanto, Timotius Ivan;Kurniawan, Andree
通讯作者：
Kurniawan, Andree
影响因子：
--
作者：
Knaak S;Mantler E;Szeto A
通讯作者：
Szeto A