Executive control network resting state fMRI functional and effective connectivity and delay discounting in cocaine dependent subjects compared to healthy controls.
Executive control network resting state fMRI functional and effective connectivity and delay discounting in cocaine dependent subjects compared to healthy controls.
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DOI：
10.3389/fpsyt.2023.1117817
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发表时间：
2023
影响因子：
4.7
通讯作者：
Moeller FG
中科院分区：
文献类型：
--
作者：
Woisard K;Steinberg JL;Ma L;Zuniga E;Lennon M;Moeller FG
静息态功能磁共振成像（fMRI）已被用于研究成瘾大脑网络的功能连接。然而，迄今为止，大多数研究都集中在默认模式网络（DMN）与执行控制网络（ECN）和显着性网络（SN）的研究评估，尽管有充分的证据表明，认知执行行为缺陷的成瘾。本研究评估了可卡因依赖受试者（CD）（n = 22）与年龄和教育程度匹配的健康对照受试者（HC）（n = 22）的ECN，DMN和SN的功能和有效连接。本研究还调查了延迟折扣测量的冲动性和ECN，DMN和SN的功能和有效连接之间的关系。左ECN（LECN），右ECN（RECN），DMN，和SN功能网络使用FSL MELODIC独立成分分析。使用FSL双回归分析和FSLNets评估CD和HC之间的功能连接差异。CD和HC之间的有效连接差异进行了测量，使用参数经验贝叶斯模块的动态因果模型。延迟折扣和功能和有效的连接之间的关系进行了研究，使用回归分析。动态因果模型（DCM）分析显示，当烟草使用作为模型中的一个因素时，CD在RECN至LECN通路中具有比HC更大的有效连接性的强有力证据（后验概率> 0.95）。DCM分析表明，延迟折扣和有效连接的RECN到LECN途径和DMN到DMN的自我连接之间存在正相关关系。有强有力的证据表明，延迟折扣与DMN至RECN通路和SN至DMN通路的有效连接之间存在负相关。结果还显示了强有力的证据表明，CD中RECN至SN通路的延迟折扣和有效连接之间存在负相关，但在HC中存在正相关。这些新的发现提供了初步的支持，RECN有效的连接可能会有所不同的CD和HC后，控制烟草使用。RECN有效连接也可能与烟草使用和冲动有关，如延迟折扣所测量的。
Resting state functional magnetic resonance imaging (fMRI) has been used to study functional connectivity of brain networks in addictions. However, most studies to-date have focused on the default mode network (DMN) with fewer studies assessing the executive control network (ECN) and salience network (SN), despite well-documented cognitive executive behavioral deficits in addictions. The present study assessed the functional and effective connectivity of the ECN, DMN, and SN in cocaine dependent subjects (CD) (n = 22) compared to healthy control subjects (HC) (n = 22) matched on age and education. This study also investigated the relationship between impulsivity measured by delay discounting and functional and effective connectivity of the ECN, DMN, and SN. The Left ECN (LECN), Right ECN (RECN), DMN, and SN functional networks were identified using FSL MELODIC independent component analysis. Functional connectivity differences between CD and HC were assessed using FSL Dual Regression analysis and FSLNets. Effective connectivity differences between CD and HC were measured using the Parametric Empirical Bayes module of Dynamic Causal Modeling. The relationship between delay discounting and functional and effective connectivity were examined using regression analyses. Dynamic causal modeling (DCM) analysis showed strong evidence (posterior probability > 0.95) for CD to have greater effective connectivity than HC in the RECN to LECN pathway when tobacco use was included as a factor in the model. DCM analysis showed strong evidence for a positive association between delay discounting and effective connectivity for the RECN to LECN pathway and for the DMN to DMN self-connection. There was strong evidence for a negative association between delay discounting and effective connectivity for the DMN to RECN pathway and for the SN to DMN pathway. Results also showed strong evidence for a negative association between delay discounting and effective connectivity for the RECN to SN pathway in CD but a positive association in HC. These novel findings provide preliminary support that RECN effective connectivity may differ between CD and HC after controlling for tobacco use. RECN effective connectivity may also relate to tobacco use and impulsivity as measured by delay discounting.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.6
作者：
Crews, Fulton Timm;Boettiger, Charlotte Ann
通讯作者：
Boettiger, Charlotte Ann
DOI：
10.1162/netn_a_00215
发表时间：
2022-03
期刊：
Network neuroscience (Cambridge, Mass.)
影响因子：
--
作者：
Frässle S;Stephan KE
通讯作者：
Stephan KE
影响因子：
3.2
作者：
Laird AR;Fox PM;Eickhoff SB;Turner JA;Ray KL;McKay DR;Glahn DC;Beckmann CF;Smith SM;Fox PT
通讯作者：
Fox PT
影响因子：
5.2
作者：
Kozak K;Lucatch AM;Lowe DJE;Balodis IM;MacKillop J;George TP
通讯作者：
George TP