One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device.
One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device.
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通过通用酶标仪和护理点设备中的低成本纳米等离子体传感器一步式快速定量 SARS-CoV-2 病毒颗粒
DOI：
10.1016/j.bios.2020.112685
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发表时间：
2021-01-01
影响因子：
12.6
通讯作者：
Liu GL
中科院分区：
文献类型：
--
作者：
Huang L;Ding L;Zhou J;Chen S;Chen F;Zhao C;Xu J;Hu W;Ji J;Xu H;Liu GL
SARS-COV-2在持续的全球大流行中的传播导致了数百万人的感染，并遭受了许多生命的损失。测量SARS-COV-2病毒颗粒几乎没有任何样品制备，使用特异性纳米质的谐振传感器在15分钟内检测到一个低至370 VP/mL的含量。泰德很快在常规临床环境和资源有限的设置下。
15分钟一步SARS-COV-2病毒颗粒检测。
没有样品处理和低成本设备和生物传感器芯片。
对不对称载体诊断的敏感。
The spread of SARS-CoV-2 virus in the ongoing global pandemic has led to infections of millions of people and losses of many lives. The rapid, accurate and convenient SARS-CoV-2 virus detection is crucial for controlling and stopping the pandemic. Diagnosis of patients in the early stage infection are so far limited to viral nucleic acid or antigen detection in human nasopharyngeal swab or saliva samples. Here we developed a method for rapid and direct optical measurement of SARS-CoV-2 virus particles in one step nearly without any sample preparation using a spike protein specific nanoplasmonic resonance sensor. As low as 370 vp/mL were detected in one step within 15 min and the virus concentration can be quantified linearly in the range of 0 to 107 vp/mL. Measurements shown on both generic microplate reader and a handheld smartphone connected device suggest that our low-cost and rapid detection method may be adopted quickly under both regular clinical environment and resource-limited settings. 15min one step SARS-CoV-2 viral particles detection. No sample processing and low-cost equipment and biosensor chip. Sensitive for asymptomatic carriers diagnosis potentially.
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