On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels.
On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels.
复制标题
DOI：
10.3389/fphys.2017.00977
复制
发表时间：
2017
影响因子：
4
通讯作者：
Tiffert T
中科院分区：
文献类型：
--
作者：
Lew VL;Tiffert T
在一个健康的成年人中，肺和组织之间的O2和CO2的运输是由大约2 · 1013个红细胞完成的，其中大约1.7 · 1011个红细胞每天更新，平均循环寿命约为120天。细胞寿命是维持细胞处于合适功能状态的能量消耗与细胞更新之间的进化平衡的结果。在这篇综述中，我们研究了成熟红细胞的被动和主动膜转运蛋白如何相互作用，以最大限度地延长其循环寿命，从而最大限度地减少昂贵的细胞周转成本。红细胞变形性对于毛细流动期间的最佳流变学和气体交换功能是关键的，当每个人红细胞的体积保持在其膜面积所允许的最大球形体积的约0.55-0.60的分数（最佳体积比范围）时，最佳地实现。在这些狭窄的最佳体积比范围内或附近可以保留红细胞体积的程度决定了循环寿命的潜力。我们表明，红细胞的低阳离子渗透性允许以非凡的成本效益实现体积稳定性，有利于细胞寿命超过细胞周转。我们提出了一种机制，通过这种机制，一个下降的钠泵和两个被动膜转运蛋白，机械敏感PIEZO 1通道，一个候选调解人的Psickle在镰状细胞，和Ca 2+敏感，K+选择性Gardos通道，可以实现红细胞体积稳定性周围的最佳体积比范围内，延长循环寿命所需的。
In a healthy adult, the transport of O2 and CO2 between lungs and tissues is performed by about 2 · 1013 red blood cells, of which around 1.7 · 1011 are renewed every day, a turnover resulting from an average circulatory lifespan of about 120 days. Cellular lifespan is the result of an evolutionary balance between the energy costs of maintaining cells in a fit functional state versus cell renewal. In this Review we examine how the set of passive and active membrane transporters of the mature red blood cells interact to maximize their circulatory longevity thus minimizing costs on expensive cell turnover. Red blood cell deformability is critical for optimal rheology and gas exchange functionality during capillary flow, best fulfilled when the volume of each human red blood cell is kept at a fraction of about 0.55–0.60 of the maximal spherical volume allowed by its membrane area, the optimal-volume-ratio range. The extent to which red blood cell volumes can be preserved within or near these narrow optimal-volume-ratio margins determines the potential for circulatory longevity. We show that the low cation permeability of red blood cells allows volume stability to be achieved with extraordinary cost-efficiency, favouring cell longevity over cell turnover. We suggest a mechanism by which the interplay of a declining sodium pump and two passive membrane transporters, the mechanosensitive PIEZO1 channel, a candidate mediator of Psickle in sickle cells, and the Ca2+-sensitive, K+-selective Gardos channel, can implement red blood cell volume stability around the optimal-volume-ratio range, as required for extended circulatory longevity.
登录
查看更多内容
影响因子：
12.8
作者：
Andolfo, Immacolata;Russo, Roberta;Iolascon, Achille
通讯作者：
Iolascon, Achille
影响因子：
4.6
作者：
Fermo, Elisa;Bogdanova, Anna;Bianchi, Paola
通讯作者：
Bianchi, Paola
影响因子：
3.4
作者：
Derganc, J;Bozic, B;Zeks, B
通讯作者：
Zeks, B
影响因子：
3.7
作者：
Dyrda, Agnieszka;Cytlak, Urszula;Thomas, Serge L. Y.
通讯作者：
Thomas, Serge L. Y.
DOI：
10.1073/pnas.1507309112
发表时间：
2015-09-22
影响因子：
11.1
作者：
Cinar, Eyup;Zhou, Sitong;Wan, Jiandi
通讯作者：
Wan, Jiandi