The Relationship Between Antidepressant Response and Tricyclic Antidepressant Plasma Concentrations
The Relationship Between Antidepressant Response and Tricyclic Antidepressant Plasma Concentrations
复制标题
抗抑郁药反应与三环类抗抑郁药血浆浓度之间的关系
作者：
P. Perry;B. Pfohl;S. Holstad
综述了三环类抗抑郁药的抗抑郁作用与其血药浓度之间的关系。逻辑回归被用作分析工具，以促进评价。目前可用的文献允许构建4个足够大小的三环数据集，以保证统计分析。对数据分布的检查和逻辑回归分析得出了关于这些药物存在“治疗窗”的几个结论。首先，阿米替林血浆浓度和治疗反应之间没有明显的关系。其次，曲线关系是明显的其他三环类抗抑郁药的研究。目前推荐的去甲替林治疗范围为60 - 150 µg/L，这是最有可能产生积极抗抑郁作用的范围。地昔帕明浓度在108至158 µg/L之间时，最常与有益的治疗反应相关。最后，观察到丙咪嗪的线性关系，其中丙咪嗪治疗血浆浓度阈值为244 εg/L及以上最常与药物的有益反应相关。
SummaryThe relationship between the antidepressant effect of the tricyclic antidepressants and their plasma concentrations was reviewed. Logistic regression was utilised as an analytical tool to facilitate the evaluation. The currently available literature allowed the construction of 4 tricyclic data sets of sufficient size to warrant statistical analysis. Inspection of the distribution of the data and the logistic regression analyses resulted in several conclusions regarding the existence of ‘therapeutic windows’ for these drugs. Firstly, no relationship between amitriptyline plasma concentrations and therapeutic response was apparent. Secondly, curvilinear relationships were apparent for 2 of the other tricyclic antidepressants studied. The currently recommended therapeutic range of 60 to 150 µg/L for nortriptyline was found to be the range most likely to produce a positive antidepressant effect. Desipramine concentrations between 108 and 158 µg/L were most commonly associated with beneficial therapeutic responses. Finally, a linear relationship was noted for Imipramine in which an Imipramine therapeutic plasma concentration threshold of 244 εg/L and above was most commonly associated with a beneficial response to the drug.
血浆去甲替林和抑郁症的临床反应。
影响因子：
6.6
作者：
Murphy,GE;Simons,AD;Wetzel,RD
通讯作者：
Wetzel,RD