Global burden of disease due to rifampicin-resistant tuberculosis: a mathematical modeling analysis.
Global burden of disease due to rifampicin-resistant tuberculosis: a mathematical modeling analysis.
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DOI：
10.1038/s41467-023-41937-9
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发表时间：
2023-10-04
影响因子：
16.6
通讯作者：
Cohen, Ted
中科院分区：
文献类型：
--
作者：
Menzies, Nicolas A.;Allwood, Brian W.;Dean, Anna S.;Dodd, Pete J.;Houben, Rein M. G. J.;James, Lyndon P.;Knight, Gwenan M.;Meghji, Jamilah;Nguyen, Linh N.;Rachow, Andrea;Schumacher, Samuel G.;Mirzayev, Fuad;Cohen, Ted
2020 年，近 50 万人患上了利福平耐药结核病 (RR-TB)。我们估计了受影响个体一生中 RR-TB 的全球负担。我们综合了 192 个国家（占全球结核病的 99.99%）的发病率、病例检测和治疗结果的数据。我们使用数学模型，预测了 2020 年结核病患者一生中的伤残调整生命年 (DALY)，按国家、年龄、性别、艾滋病毒和利福平耐药性进行分层。在这里，我们显示，2020 年的 RR-TB 事件造成了估计 6.9（95% 不确定区间：5.5, 8.5）百万 DALY，其中 44%（31, 54）发生在结核病幸存者中。我们估计，患 RR-TB 的人平均有 17 (14, 21) DALY，比利福平敏感结核病高 34% (12, 56)。每 10 万人中的 RR-TB 负担在前苏联国家和南部非洲国家中最高。虽然 RR-TB 会导致大量的短期发病率和死亡率，但 RR-TB 总体疾病负担的近一半是由结核病幸存者承担的。利福平结核病幸存者的长期健康影响表明需要改善治疗后护理，并进一步证明增加卫生支出以预防利福平结核病传播是合理的。与利福平敏感的疾病相比，利福平耐药结核病 (RR-TB) 需要更长的时间、毒性更大的治疗，并且与长期后遗症的发生率更高有关。在这项数学模型研究中，作者估计 2020 年 RR-TB 事件将造成约 690 万伤残调整生命年； 44%是由于结核病后遗症所致。
In 2020, almost half a million individuals developed rifampicin-resistant tuberculosis (RR-TB). We estimated the global burden of RR-TB over the lifetime of affected individuals. We synthesized data on incidence, case detection, and treatment outcomes in 192 countries (99.99% of global tuberculosis). Using a mathematical model, we projected disability-adjusted life years (DALYs) over the lifetime for individuals developing tuberculosis in 2020 stratified by country, age, sex, HIV, and rifampicin resistance. Here we show that incident RR-TB in 2020 was responsible for an estimated 6.9 (95% uncertainty interval: 5.5, 8.5) million DALYs, 44% (31, 54) of which accrued among TB survivors. We estimated an average of 17 (14, 21) DALYs per person developing RR-TB, 34% (12, 56) greater than for rifampicin-susceptible tuberculosis. RR-TB burden per 100,000 was highest in former Soviet Union countries and southern African countries. While RR-TB causes substantial short-term morbidity and mortality, nearly half of the overall disease burden of RR-TB accrues among tuberculosis survivors. The substantial long-term health impacts among those surviving RR-TB disease suggest the need for improved post-treatment care and further justify increased health expenditures to prevent RR-TB transmission. Rifampicin-resistant tuberculosis (RR-TB) requires longer, more toxic therapy than rifampicin-sensitive disease and is associated with a higher occurrence of long-term sequelae. In this mathematical modeling study, the authors estimate that incident RR-TB in 2020 will be responsible for ~6.9 million disability-adjusted life years; 44% due to post-tuberculosis sequelae.
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影响因子：
13.8
作者：
Lee-Rodriguez C;Wada PY;Hung YY;Skarbinski J
通讯作者：
Skarbinski J
影响因子：
15.1
作者：
Akalu, Temesgen Yihunie;Clements, Archie C. A.;Wolde, Haileab Fekadu;Alene, Kefyalew Addis
通讯作者：
Alene, Kefyalew Addis
影响因子：
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作者：
通讯作者：
--
影响因子：
3.6
作者：
Briggs, Andrew H.;Weinstein, Milton C.;Paltiel, A. David
通讯作者：
Paltiel, A. David
DOI：
10.5588/ijtld.21.0425
发表时间：
2021-10-01
影响因子：
4
作者：
Migliori, G. B.;Marx, F. M.;Visca, D.
通讯作者：
Visca, D.