Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study.
Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study.
复制标题
作者：
结核病后（post-TB）肺部疾病是肺结核（pTB）的一种未被充分认识的后果。我们的目的是估计pTB治疗完成后儿童残余肺功能损害和健康相关生活质量（HRQoL）降低的患病率。我们对结核病诊断时年龄小于15岁的儿童进行了一项横断面比较研究，这些儿童至少在6个月前完成了pTB治疗，并与年龄匹配的无pTB病史的儿童进行了比较。收集症状、肺功能测定和PedsQL量表测量的HRQoL。通过逻辑回归模型识别与肺功能损害相关的变量。我们纳入了68例结核病后病例（中位年龄8.9（IQR 7.2-11.2）岁）和91例对照组儿童（11.5（8.0-13.7）岁）。52例（76.5%）TB后病例和89例（94.5%）对照组的肺功能测定符合可接受性和可重复性的质量标准。肺功能损害存在于20/52例（38.5%）TB后病例和15/86例（17.4%）对照组中，p=0.009。既往pTB和慢性咳嗽史与肺功能损害显著相关（分别为p=0.047和0.006）。与对照组相比，TB后病例的第1秒用力呼气量（FEV 1）、用力肺活量（FVC）和FEV 1/FVC z评分显著降低（分别为p= <0.001、0.014和<0.001）。与对照组相比，结核病后病例的自我报告的身体健康评分以及父母报告的身体、情感、心理、社会和总HRQoL评分的分布明显较低。儿童既往患结核病与肺功能和HRQoL显著受损相关。
Post-tuberculosis (post-TB) lung disease is an under-recognised consequence of pulmonary tuberculosis (pTB). We aimed to estimate the prevalence of residual lung function impairment and reduced health-related quality of life (HRQoL) in children after pTB treatment completion. We conducted a cross-sectional comparative study of children aged less than 15 years at TB diagnosis who had completed treatment for pTB at least 6 months previously with a comparator group of age-matched children without a history of pTB. Symptoms, spirometry and HRQoL measured with PedsQL scale were collected. Variables associated with lung function impairment were identified through logistic regression models. We enrolled 68 post-TB cases (median age 8.9 (IQR 7.2–11.2) years) and 91 children in the comparison group (11.5 (8.0–13.7) years). Spirometry from 52 (76.5%) post-TB cases and 89 (94.5%) of the comparison group met the quality criteria for acceptability and repeatability. Lung function impairment was present in 20/52 (38.5%) post-TB cases and 15/86 (17.4%) in the comparison group, p=0.009. Previous pTB and a history of chronic cough were significantly associated with the presence of lung function impairment (p=0.047 and 0.006 respectively). Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC z-scores were significantly lower in the post-TB cases compared with the comparison group (p= <0.001, 0.014 and <0.001, respectively). The distribution of the self-reported physical health score, and parent-reported physical, emotional, psychological, social and total HRQoL scores were significantly lower in the post-TB cases compared with the comparison group. Previous TB in children is associated with significantly impaired lung function and HRQoL.
登录
查看更多内容
3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
The European respiratory journal
影响因子：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
通讯作者：
ERS Global Lung Function Initiative
DOI：
10.1183/13993003.02325-2014
发表时间：
2015-10
期刊：
The European respiratory journal
影响因子：
--
作者：
Amaral AF;Coton S;Kato B;Tan WC;Studnicka M;Janson C;Gislason T;Mannino D;Bateman ED;Buist S;Burney PG;BOLD Collaborative Research Group
通讯作者：
BOLD Collaborative Research Group
DOI：
10.7196/ajtccm.2021.v27i2.135
发表时间：
2021
影响因子：
--
作者：
Ozoh OB;Ojo OO;Dania MG;Dede SK;Adegboyega OA;Irurhe NK;Olowoyeye M;Adeyeye OO
通讯作者：
Adeyeye OO
影响因子：
8
作者：
Chan, Johnny Y. C.;Stern, Debra A.;Martinez, Fernando D.
通讯作者：
Martinez, Fernando D.
影响因子：
5.8
作者：
Bush, Andrew
通讯作者：
Bush, Andrew