The patterns of deleterious mutations during the domestication of soybean.

The patterns of deleterious mutations during the domestication of soybean.
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DOI:
10.1038/s41467-020-20337-3
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发表时间:
2021-01-04
影响因子:
16.6
通讯作者:
Jeong SC
Jeong SC
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Kim MS;Lozano R;Kim JH;Bae DN;Kim ST;Park JH;Choi MS;Kim J;Ok HC;Park SK;Gore MA;Moon JK;Jeong SC

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Globally, soybean is a major protein and oil crop. Enhancing our understanding of the soybean domestication and improvement process helps boost genomics-assisted breeding efforts. Here we present a genome-wide variation map of 10.6 million single-nucleotide polymorphisms and 1.4 million indels for 781 soybean individuals which includes 418 domesticated (Glycine max), 345 wild (Glycine soja), and 18 natural hybrid (G. max/G. soja) accessions. We describe the enhanced detection of 183 domestication-selective sweeps and the patterns of putative deleterious mutations during domestication and improvement. This predominantly selfing species shows 7.1% reduction of overall deleterious mutations in domesticated soybean relative to wild soybean and a further 1.4% reduction from landrace to improved accessions. The detected domestication-selective sweeps also show reduced levels of deleterious alleles. Importantly, genotype imputation with this resource increases the mapping resolution of genome-wide association studies for seed protein and oil traits in a soybean diversity panel. The accumulation of recombination events in selfing species may lead to a rapid fixation of both beneficial and deleterious mutations. Here, the authors resequence 781 soybean accessions, show purging of deleterious mutation during domestication, and report genome-wide associations for seed protein and oil traits.
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