Glycyrrhizic acid in the treatment of liver diseases: literature review.

Glycyrrhizic acid in the treatment of liver diseases: literature review.
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甘草酸治疗肝病的文献综述

DOI:
10.1155/2014/872139
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发表时间:
2014
影响因子:
--
通讯作者:
Sun MY
Sun MY
中科院分区:
生物学3区
文献类型:
--
作者:
Li JY;Cao HY;Liu P;Cheng GH;Sun MY

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甘草酸(glycyrrhizicacid,GA)是一种存在于甘草(Glycyrrhiza glabra)根中的三萜糖苷。GA是甘草中最重要的活性成分,具有广泛的药理和生物活性。GA与甘草次酸和18-β-甘草次酸偶联,在中国或日本被开发为抗炎、抗病毒和抗过敏药物,用于治疗肝病。本文就GA的生物学活性及其在肝脏疾病中的应用作一综述。GA的药理作用包括抑制肝细胞凋亡和坏死;抗炎和免疫调节作用;抗病毒作用;和抗肿瘤作用。本文的研究将为临床医生和生物学家研究GA提供有益的参考,并为中药新药的发现和开发开辟新的途径。通过进一步的研究,GA可以更广泛地用于肝病或其它病症的治疗。
Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. This paper will be a useful reference for physicians and biologists researching GA and will open the door to novel agents in drug discovery and development from Chinese herbs. With additional research, GA may be more widely used in the treatment of liver diseases or other conditions.
DOI: 10.1023/b:ddas.0000011604.45531.2c
发表时间: 2004-01-01
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