Adenoviruses associated with acute diarrhea in children in Beijing, China.
Adenoviruses associated with acute diarrhea in children in Beijing, China.
复制标题
DOI：
10.1371/journal.pone.0088791
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Dong H
中科院分区：
文献类型：
--
作者：
Liu L;Qian Y;Zhang Y;Deng J;Jia L;Dong H
腺病毒已被认为是儿童社区获得性腹泻（CAD）的重要致病病原体，但其在医院获得性腹泻（HAD）中的作用尚不清楚。对2011 - 2012年住院的急性腹泻患儿和因腹泻就诊的门诊患儿进行调查。采用PCR方法在粪便标本中检测到腺病毒，并对其进行测序和系统发育分析。采用SPSS 19.0版软件进行统计分析。共有2233名腹泻儿童被纳入本研究；该样本由1371名住院儿童组成，包括885名CAD （IP-CAD）和486名HAD，以及862名CAD （OP-CAD）门诊患者。2233例患者中检出腺病毒219例（9.8%）。腺病毒阳性率在IP-CAD（9.3%）、HAD（13.8%）和OP-CAD（8.1%）之间差异有统计学意义（X2 = 11.76, p = 0.003）。与其他年龄组的阳性率相比，六个月以下婴儿的腺病毒阳性率较低。219例腺病毒阳性患者中，91例（41.6%）血清型为41型。尽管肠内腺病毒（F组）是CAD或HAD患儿中最常检测到的腺病毒，但非肠内腺病毒，特别是31型腺病毒（19.7%）在腹泻患儿中的作用也不容忽视。
Adenoviruses have been recognized as important causal pathogens of community-acquired diarrhea (CAD) among children, but their role in hospital-acquired diarrhea (HAD) is not well-understood. Hospitalized children with acute diarrhea and children who visited the outpatient department due to diarrhea were investigated from 2011 to 2012. Adenovirus was detected in stool specimens by PCR and further characterized by sequencing and phylogenetic analysis. SPSS software (version 19.0) was used for statistical analyses. A total of 2233 diarrheal children were enrolled in this study; this sample was comprised of 1371 hospitalized children, including 885 with CAD (IP-CAD) and 486 with HAD, and 862 outpatients with CAD (OP-CAD). Among these 2,233 patients, adenovirus was detected in 219 cases (9.8%). The positive rates for adenovirus were significantly different between the IP-CAD (9.3%), HAD (13.8%) and OP-CAD (8.1%) cases (X2 = 11.76, p = 0.003). The positive rate of adenovirus was lower in infants under six months of age compared to the positive rates in the other age groups. Of the 219 of adenovirus positive patients, 91 (41.6%) were identified as having serotype 41. Although enteric adenovirus (group F) was the most frequently detected adenovirus among children with either CAD or HAD, the role of non-enteric adenoviruses, especially the adenovirus 31 type (19.7%), cannot be ignored in diarrheal children.
登录
查看更多内容
影响因子：
3.7
作者：
Festini, Filippo;Cocchi, Priscilla;de Martino, Maurizio
通讯作者：
de Martino, Maurizio
影响因子：
9.4
作者：
BROWN, M
通讯作者：
BROWN, M
影响因子：
2.7
作者：
Akihara, S;Phan, TG;Ushijima, H
通讯作者：
Ushijima, H
影响因子：
4.5
作者：
Langley, JM;LeBlanc, JC;Goloubeva, O
通讯作者：
Goloubeva, O
影响因子：
9.4
作者：
Allard, A;Albinsson, B;Wadell, G
通讯作者：
Wadell, G