Impact of stressing conditions and polymer–surfactant interactions on product characteristics of organic nanoparticles produced by media milling
Impact of stressing conditions and polymer–surfactant interactions on product characteristics of organic nanoparticles produced by media milling
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应力条件和聚合物-表面活性剂相互作用对介质研磨产生的有机纳米颗粒产品特性的影响
DOI：
10.1016/j.powtec.2016.02.016
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发表时间：
2016
影响因子：
5.2
通讯作者：
W. Peukert
中科院分区：
文献类型：
--
作者：
C. Konnerth;F. Flach;S. Breitung;C. Damm;Jochen Schmidt;A. Kwade;W. Peukert
以乙烯基吡咯烷酮-醋酸乙烯酯共聚物（KVA 64）、十二烷基硫酸钠（SDS）和羟丙基纤维素（HPC-SSL）为稳定剂，对多环芳烃芘在水环境下的搅拌介质制粉制备有机纳米颗粒进行了研究。给出了用应力能、应力数和质量比能输入描述的应力条件对产品粒度的影响。在相同的应力和配方条件下，间歇和连续操作的磨矿动力学具有可比性。此外，研究发现，使用小的研磨介质，即低应力能和高应力数的应力条件，对于快速动力学和最小的能量消耗是有利的。此外，产品特性和配方参数之间的关系，即稳定剂的类型和浓度进行了深入的研究。通过张力测定法和荧光光谱法证实了KVA 64与SDS的络合物形成。研究表明，芘的增溶作用发生在系统中，产物特性不仅取决于纯粹的断裂事件或胶体稳定性问题，还取决于溶解和成熟现象：在类似的应力条件下，在增溶作用和成熟作用不太明显的条件下，观察到最小的产物粒径，而在高增溶能力的系统中观察到较大的产物颗粒。
Stirred media milling as a feasible method to produce organic nanoparticles was studied for the polycyclic aromatic hydrocarbon pyrene in aqueous environment using vinylpyrrolidone-vinyl acetate copolymer (KVA 64) and sodium dodecyl sulphate (SDS) as well as hydroxypropylcellulose (HPC-SSL) as stabilising agents during batch and continuous processing. The influence of stressing conditions described by means of stress energy, stress number as well as mass-specific energy input on product particle sizes is presented. Grinding kinetics observed for batch and continuous operation are comparable under similar stressing and formulation conditions. Furthermore, it was found that the use of small grinding media, i.e. stress conditions where low stress energies and high stress numbers apply, are advantageous with respect to fast kinetics and minimum energy consumption. Moreover, the relationship between product characteristics and formulation parameters, i.e. type and concentration of stabilising agents are thoroughly investigated. Complex formation of KVA 64 and SDS has been proven by means of tensiometry and fluorescence spectroscopy. It is demonstrated that solubilisation of pyrene occurs in the system and that product characteristics are not only determined by pure breakage events or colloidal stability issues but also by dissolution and ripening phenomena: Minimum product particle sizes at similar stressing conditions are observed under conditions where solubilisation and ripening are less pronounced, whereas larger product particles are observed in systems with high solubilisation capacities.
影响因子：
3.9
作者：
Stefan Romeis;A. Hoppe;C. Eisermann;N. Schneider;A. Boccaccini;Jochen Schmidt;W. Peukert
通讯作者：
Stefan Romeis;A. Hoppe;C. Eisermann;N. Schneider;A. Boccaccini;Jochen Schmidt;W. Peukert