Tuberculosis outcomes in Papua, Indonesia: the relationship with different body mass index characteristics between papuan and non-Papuan ethnic groups.
Tuberculosis outcomes in Papua, Indonesia: the relationship with different body mass index characteristics between papuan and non-Papuan ethnic groups.
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DOI：
10.1371/journal.pone.0076077
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ralph AP
中科院分区：
文献类型：
--
作者：
Kenangalem E;Waramori G;Pontororing GJ;Sandjaja;Tjitra E;Maguire G;Kelly PM;Anstey NM;Ralph AP
肺结核（PTB）治疗期间体重增加与细菌学治疗成功的可能性相关。人们认识到，体重和身体质量指数（BMI）的特点在健康和疾病状态的种族群体之间存在差异。然而，之前没有研究BMI的种族差异如何影响结核病治疗结果。我们的目的是调查在印度尼西亚巴布亚省Timika结核病诊所对PTB治疗的微生物学反应的预测因素，特别是确定种族的贡献。人口由两个不同的族裔群体组成-亚洲人（非巴布亚人）和美拉尼西亚人（巴布亚人）。我们对涂阳肺结核成人患者进行了一项前瞻性研究。治疗结果为1个月和2个月的痰培养以及显微镜检查转换的时间。临床指标包括体重、BMI、胸片、肺功能（包括1秒用力呼气量（FEV 1））和血红蛋白。186名受试者（83名巴布亚人，103名非巴布亚人）入组。基线时，巴布亚人的平均体重和BMI高于非巴布亚人（分别为50.0 kg vs 46.9 kg，p = 0.006和20.0 kg/m2 vs 18.7 kg/m2，p = 0.001）。 尽管平均血红蛋白较低（11.3 vs 13.1 g/dL，p<0.0001），吸烟率和HIV感染率较高（分别为37% vs 21%，p = 0.02和20% vs 5%，p = 0.01），中位病程较长（3 vs 2个月，p = 0.04），但放射学严重程度（空洞比例55% vs 57%，p = 0.7），痰涂片分级（p = 0.3）和平均%预测FEV 1（63% vs 64%，p = 0.7）相似。 在单变量和多变量分析中，控制了其他可能的文化转换决定因素，到2个月时，巴布亚人体重增加更多（平均5.9 vs 4.2 kg，p = 0.02），痰培养阴性的可能性更大（49/56 vs 45/67，p =0.02）。 总之，巴布亚人PTB治疗的早期微生物学结果更好，这可能与更好地保持体重和更大的早期体重增加有关。
Weight gain achieved during pulmonary tuberculosis (PTB) treatment is associated with the likelihood of bacteriological treatment success. It is recognised that weight and body mass index (BMI) characteristics differ between ethnic groups in health and illness states. However there has been no prior investigation of how ethnic differences in BMI might influence tuberculosis treatment outcome. Our aim was to investigate predictors of microbiological response to PTB treatment at the Tuberculosis Clinic in Timika, Papua Province, Indonesia and specifically, to determine the contribution of ethnicity. The population comprises two distinct ethnic groups - Asian (Non-Papuan) and Melanesian (Papuan). We conducted a prospective study of adults with smear-positive PTB. Treatment outcomes were 1- and 2-month sputum culture and time to microscopy conversion. Clinical measures included weight, BMI, chest radiograph, pulmonary function including forced expiratory volume in 1 second (FEV1) and haemoglobin. One hundred eighty six participants (83 Papuan, 103 non-Papuan Indonesians) were enrolled. At baseline, Papuans had higher mean weight and BMI than non-Papuans (50.0 kg versus 46.9 kg, p = 0.006 and 20.0 kg/m2 versus 18.7 kg/m2, p = 0.001 respectively). This was despite having lower mean haemoglobin (11.3 vs 13.1 g/dL, p<0.0001), higher smoking and HIV rates (37% vs 21%, p = 0.02 and 20% vs 5%, p = 0.01 respectively) and longer median illness duration (3 vs 2 months, p = 0.04), but similar radiological severity (proportion with cavities 55% vs 57%, p = 0.7), sputum smear grade (p = 0.3) and mean % predicted FEV1 (63% vs 64%, p = 0.7). By 2 months, Papuans had gained still more weight (mean 5.9 vs 4.2 kg, p = 0.02), and were more likely to have negative sputum culture (49/56 vs 45/67, p = 0.02), in univariable and multivariable analyses controlling for other likely determinants of culture conversion. In conclusion, Papuans had better early microbiological outcome from PTB treatment, which may relate to better preservation of weight and greater early weight gain.
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影响因子：
10
作者：
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通讯作者：
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DOI：
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发表时间：
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DOI：
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发表时间：
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影响因子：
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