Plasma adipokines and glycaemic progression among African Americans: Findings from the Jackson Heart Study.
Plasma adipokines and glycaemic progression among African Americans: Findings from the Jackson Heart Study.
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DOI：
10.1111/dme.14465
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发表时间：
2021-05
影响因子：
3.5
通讯作者：
Echouffo-Tcheugui, Justin B.
中科院分区：
文献类型：
--
作者：
Kaze, Arnaud D.;Musani, Solomon K.;Bidulescu, Aurelian;Joseph, Joshua J.;Correa, Adolfo;Ndumele, Chiadi E.;Bertoni, Alain G.;Ahima, Rexford S.;Golden, Sherita H.;Echouffo-Tcheugui, Justin B.
目的：在以社区为基础的非裔美国人(AAS)样本中，评估包括瘦素、脂联素、脂联素/瘦素比值和高敏C反应蛋白(HsCRP)在内的血浆生物标记物与血糖进展和发生血糖紊乱(糖尿病前期或糖尿病)的风险之间的关系。我们分析了3223名在基线(2000年至2004年)没有2型糖尿病的参与者的数据，他们参加了≥1的随访。泊松回归被用来产生血糖进展和发生血糖异常的风险比(RR)。在中位数7年的时间里，46.4%的患者发生了血糖进行性进展(n=1495)。调整人口学和生活方式变量后，瘦素、脂联素、脂联素/瘦素比值和hsCRP对血糖进展的相对危险度(95%CI)分别为1.30(1.10-1.54)、0.74(0.65-0.84)、0.70(0.62-0.80)和1.22(1.07-1.38)。在进一步调整BMI后，相应的RR(95%CI)分别为1.15(0.94-1.42)、0.76(0.67-0.86)、0.72(0.62-0.84)和1.14(0.99-1.31)。在血糖正常的受试者中，瘦素、脂联素、脂联素/瘦素比值和hsCRP在Q4与Q1发生糖尿病前期的RRS(95%Cis)分别为1.37(1.13~1.67)、0.73(0.63~0.85)、0.70(0.59~0.82)和1.28(1.10~1.48)；发生糖尿病的当量相对危险度分别为5.15(2.63~10.10)、0.36(0.20~0.68)、0.21(0.12~0.38)和3.04(1.70~5.44)。在这个以社区为基础的大型AA队列中，我们的结果表明，高血浆瘦素和hsCRP，以及低脂联素和脂联素/瘦素比率，与更高的血糖进展风险相关。这些发现表明，这些生物标志物在预测和预防这一高危人群中的血糖进展方面具有潜在的实用价值。
To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponectin-to-leptin ratio and high-sensitivity C-reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre-diabetes or diabetes) in a community-based sample of African American (AAs). We analysed data from 3223 participants without type 2 diabetes at baseline (2000–2004) who attended ≥1 follow-up visit. Poisson regression was used to generate risk ratios (RRs) for glycaemic progression and incident dysglycaemia. Over a median of 7 years, 46.4% developed glycaemic progression (n=1495). After adjusting for demographic and lifestyle variables, the RRs (95% CI) for glycaemic progression comparing highest (Q4) to lowest (Q1) quartiles were 1.30 (1.10–1.54), 0.74 (0.65–0.84), 0.70 (0.62–0.80) and 1.22 (1.07–1.38) for leptin, adiponectin, adiponectin–leptin ratio and hsCRP, respectively. Upon additional adjustment for BMI, the corresponding RRs (95% CIs) were 1.15 (0.94–1.42), 0.76 (0.67–0.86), 0.72 (0.62–0.84) and 1.14 (0.99–1.31) respectively. Among participants with normal glycaemia, the RRs (95% CIs) for incident pre-diabetes in Q4 vs Q1 were 1.37 (1.13–1.67), 0.73 (0.63–0.85), 0.70 (0.59–0.82) and 1.28 (1.10–1.48) for leptin, adiponectin, adiponectin–leptin ratio and hsCRP, respectively; equivalent RRs for incident diabetes were 5.15 (2.63–10.10), 0.36 (0.20–0.68), 0.21 (0.12–0.38) and 3.04 (1.70–5.44), respectively. In this large community-based cohort of AAs, our results suggest that high plasma leptin and hsCRP, as well as low adiponectin and adiponectin-to-leptin ratio, are associated with higher risks of glycaemic progression. The findings point to the potential utility of these biomarkers in predicting and preventing glycaemic progression in this high-risk population.
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影响因子：
7.7
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