Role of Polyphenol-Derived Phenolic Acid in Mitigation of Inflammasome-Mediated Anxiety and Depression.
Role of Polyphenol-Derived Phenolic Acid in Mitigation of Inflammasome-Mediated Anxiety and Depression.
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DOI：
10.3390/biomedicines10061264
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发表时间：
2022-05-28
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
在一生中过度暴露于精神压力是发展神经精神障碍的一个重要风险因素，包括抑郁和焦虑。免疫系统可以启动一种生理反应，释放应激激素和促炎细胞因子，以回应应激源。这些效应可以克服不稳定的生理机制，如果长期发生，会产生有害的促炎环境。我们实验室以前的研究已经确定了生物可用多酚制剂BDPP的关键抗炎特性，以及它通过减弱NLRP3炎症体依赖反应来缓解应激反应的能力。炎性小体激活是抵抗不同性质刺激的第一道防线的一部分，提供快速反应，因此在先天免疫反应中至关重要。葡萄糖苷-3-O-葡萄糖苷(MG)是葡萄中含量较高的一种天然花色苷，具有抗炎作用，但其作用机制尚不清楚。本研究旨在阐明MG在体外和在慢性不可预测应激(CUS)小鼠模型中对炎症性炎症的治疗潜力。在这里，它是一种抗焦性酚类代谢产物，靶向NLRP3，NLRC4和AIM2炎性小体，从而降低小鼠原代皮质小胶质细胞和脑中caspase-1和IL-1β的蛋白水平，同时也证明了其对抗焦虑和抑郁的有益作用。本研究支持MG在体外减轻细菌介导的炎症(脂多糖或内毒素)的作用，以及在体内CUS诱导的行为损害以应对应激诱导的炎症体介导的先天反应。
Overexposure to mental stress throughout life is a significant risk factor for the development of neuropsychiatric disorders, including depression and anxiety. The immune system can initiate a physiological response, releasing stress hormones and pro-inflammatory cytokines, in response to stressors. These effects can overcome allostatic physiological mechanisms and generate a pro-inflammatory environment with deleterious effects if occurring chronically. Previous studies in our lab have identified key anti-inflammatory properties of a bioavailable polyphenolic preparation BDPP and its ability to mitigate stress responses via the attenuation of NLRP3 inflammasome-dependent responses. Inflammasome activation is part of the first line of defense against stimuli of different natures, provides a rapid response, and, therefore, is of capital importance within the innate immunity response. malvidin-3-O-glucoside (MG), a natural anthocyanin present in high proportions in grapes, has been reported to exhibit anti-inflammatory effects, but its mechanisms remain poorly understood. This study aims to elucidate the therapeutic potential of MG on inflammasome-induced inflammation in vitro and in a mouse model of chronic unpredictable stress (CUS). Here, it is shown that MG is an anti-pyroptotic phenolic metabolite that targets NLRP3, NLRC4, and AIM2 inflammasomes, subsequently reducing caspase-1 and IL-1β protein levels in murine primary cortical microglia and the brain, as its beneficial effect to counteract anxiety and depression is also demonstrated. The present study supports the role of MG to mitigate bacterial-mediated inflammation (lipopolysaccharide or LPS) in vitro and CUS-induced behavior impairment in vivo to address stress-induced inflammasome-mediated innate response.
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DOI：
10.3390/molecules190812827
发表时间：
2014-08-21
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
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Li CY
DOI：
10.1073/pnas.0611496104
发表时间：
2007-05-08
影响因子：
11.1
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Ting, Jenny Pan-Yun
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
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DOI：
10.3233/jad-2009-1135
发表时间：
2009
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
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作者：
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通讯作者：
Pasinetti GM
影响因子：
8.6
作者：
Chear, Chai Teng;Nallusamy, Revathy;Bin Mohamad, Saharuddin
通讯作者：
Bin Mohamad, Saharuddin