Epigenetics and Oxidative Stress in Aging.
Epigenetics and Oxidative Stress in Aging.
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DOI：
10.1155/2017/9175806
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发表时间：
2017
影响因子：
--
通讯作者：
Sandoval J
中科院分区：
文献类型：
--
作者：
Guillaumet-Adkins A;Yañez Y;Peris-Diaz MD;Calabria I;Palanca-Ballester C;Sandoval J
衰老是一个多因素的过程，其特征是生理功能的逐渐丧失，导致对年龄相关疾病的易感性增加，最终导致死亡。人们提出了几种理论来解释衰老的本质。最著名的发现之一是线粒体新陈代谢产生的自由基是细胞和DNA损伤的原因。然而，也有一些证据支持表观遗传修饰，如DNA甲基化、非编码RNA和组蛋白修饰，在衰老的分子机制中发挥关键作用。在这篇综述中，我们探讨了这些发现的意义，并讨论了氧化应激和表观遗传学的相互关联的影响如何解释与年龄相关的下降的原因。
Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging. In this review, we explore the significance of these findings and argue how the interlinked effects of oxidative stress and epigenetics can explain the cause of age-related declines.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
3.7
作者：
Bocklandt S;Lin W;Sehl ME;Sánchez FJ;Sinsheimer JS;Horvath S;Vilain E
通讯作者：
Vilain E
影响因子：
7.8
作者：
Dai DF;Karunadharma PP;Chiao YA;Basisty N;Crispin D;Hsieh EJ;Chen T;Gu H;Djukovic D;Raftery D;Beyer RP;MacCoss MJ;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
56.9
作者：
Boehm, M;Slack, F
通讯作者：
Slack, F
影响因子：
56.9
作者：
Bostick, Magnolia;Kim, Jong Kyong;Jacobsen, Steven E.
通讯作者：
Jacobsen, Steven E.