Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects.
Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects.
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DOI：
10.1289/ehp.9234
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发表时间：
2006-09
影响因子：
10.4
通讯作者：
Mauderly JL
中科院分区：
文献类型：
--
作者：
Seagrave J;McDonald JD;Bedrick E;Edgerton ES;Gigliotti AP;Jansen JJ;Ke L;Naeher LP;Seilkop SK;Zheng M;Mauderly JL
暴露于空气污染，更具体地说，颗粒物（PM）与不良健康影响有关。然而，负责生物效应的具体PM特性尚未定义。在这个项目中，我们研究了两个季节中从东南部气溶胶研究和表征（SESS）空气监测网络中收集的空气动力学直径≥2.5 μm（PM2.5）的PM样品的组成，来源和相对毒性。这些站点代表了PM2.5来源不同的四个区域，包括当地城市与区域来源，交通和工业来源贡献不同的城市地区，以及受墨西哥湾天气模式影响的站点。我们在2004年冬季和夏季从每个站点收集样品进行毒性测试和化学分析和基于化学质量平衡的源解析。我们还收集了一系列规定的森林燃烧下风向的PM2.5。我们通过滴注到大鼠肺中评估了样品的毒性，并评估了一般毒性、急性细胞毒性和炎症。使用统计剂量反应模型技术对相对毒性进行排序，并比较每个站点的季节差异。投影-潜表面（PLS）技术研究了来源、化学成分和毒理学终点之间的关系。来自车辆和工业的高贡献的城市站点是最有毒的。
Exposure to air pollution and, more specifically, particulate matter (PM) is associated with adverse health effects. However, the specific PM characteristics responsible for biological effects have not been defined. In this project we examined the composition, sources, and relative toxicity of samples of PM with aerodynamic diameter ≥2.5 μm (PM2.5) collected from sites within the Southeastern Aerosol Research and Characterization (SEARCH) air monitoring network during two seasons. These sites represent four areas with differing sources of PM2.5, including local urban versus regional sources, urban areas with different contributions of transportation and industrial sources, and a site influenced by Gulf of Mexico weather patterns. We collected samples from each site during the winter and summer of 2004 for toxicity testing and for chemical analysis and chemical mass balance–based source apportionment. We also collected PM2.5 downwind of a series of prescribed forest burns. We assessed the toxicity of the samples by instillation into rat lungs and assessed general toxicity, acute cytotoxicity, and inflammation. Statistical dose–response modeling techniques were used to rank the relative toxicity and compare the seasonal differences at each site. Projection-to-latent-surfaces (PLS) techniques examined the relationships among sources, chemical composition, and toxicologic end points. Urban sites with high contributions from vehicles and industry were most toxic.
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影响因子：
3.4
作者：
OBERDORSTER, G
通讯作者：
OBERDORSTER, G
影响因子：
3.8
作者：
Costa, DL;Lehmann, JR;Dreher, KL
通讯作者：
Dreher, KL
影响因子：
3.8
作者：
Driscoll, KE;Costa, DL;Schlesinger, RB
通讯作者：
Schlesinger, RB
影响因子：
10.4
作者：
Gurgueira SA;Lawrence J;Coull B;Murthy GG;González-Flecha B
通讯作者：
González-Flecha B
影响因子：
4.1
作者：
Karlsson, HL;Nilsson, L;Möller, L
通讯作者：
Möller, L