Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS.
Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS.
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DOI：
10.1002/nbm.1595
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发表时间：
2011-04
影响因子：
2.9
通讯作者：
Su, M. -Y.
中科院分区：
文献类型：
--
作者：
Chen, J. -H.;Mehta, R. S.;Baek, H. -M.;Nie, K.;Liu, H.;Lin, M. Q.;Yu, H. J.;Nalcioglu, O.;Su, M. -Y.
本研究旨在探讨tCho与乳腺癌临床特征和生物标志物状态的关系。本文对62例1.5cm以上的乳腺癌患者进行了MRI检查。tCho浓度与MR成像特征、对比增强动力学、临床变量和生物标志物相关。采用成对双尾斯皮尔曼非参数检验进行统计分析。tCho在高级别肿瘤中高于中/低级别肿瘤（p=0.04），并且在具有较高Ktranss和kep的肿瘤中高于中/低级别肿瘤（两者均为p<0.001）。tCho与年龄（p=0.05）和三阴性生物标志物（p=0.09）的关联接近显著性。17例患者未检测到tCho，其中15例浸润性导管癌和2例浸润性小叶癌。17名患者中有15名患有中度至低度癌症，11名患有HER-2阴性癌症，这表明这两个因素可能导致胆碱假阴性。高级别肿瘤和具有较高Ktranss和kep的肿瘤中较高的tCho表明胆碱与细胞增殖和肿瘤血管生成相关。年轻女性的胆碱水平较高可能是由于其更具侵袭性的肿瘤类型。本文结果有助于更好地解释1H MRS对乳腺病变的诊断。
This study was to investigate the association between tCho and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer which was 1.5 cm or larger in size on MR images were studied. The tCho concentration was correlated with the MR imaging features, the contrast enhancement kinetics, clinical variables, and biomarkers. Pair-wise two-tailed Spearman’s non-parametric test was used for the statistical analysis. The tCho was higher in high grade than moderate/low grade tumor (p=0.04) and in tumors with higher Ktrans and kep (p<0.001 for both). The association of tCho with age (p=0.05) and triple negative biomarker (p=0.09) approached significance. tCho was not detected in 17 patients, including 15 invasive ductal cancer and 2 infiltrating lobular cancer. Fifteen of the 17 patients had moderate to low grade cancers, and 11 had HER-2 negative cancer, suggesting these two factors might lead to false negative choline. Higher tCho in high grade tumors and tumors with higher Ktrans and kep indicates choline is associated with cell proliferation and tumor angiogenesis. Higher choline level in younger women may be due to their more aggressive tumor type. The results presented here may aid in better interpretation of 1H MRS for diagnosis of breast lesions.
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影响因子：
4.4
作者：
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