Brain Volumetric Measurements in Children With Attention Deficit Hyperactivity Disorder: A Comparative Study Between Synthetic and Conventional Magnetic Resonance Imaging.
Brain Volumetric Measurements in Children With Attention Deficit Hyperactivity Disorder: A Comparative Study Between Synthetic and Conventional Magnetic Resonance Imaging.
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DOI：
10.3389/fnins.2021.711528
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发表时间：
2021
影响因子：
4.3
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Chen Y;Su S;Dai Y;Wen Z;Qian L;Zhang H;Liu M;Fan M;Chu J;Yang Z
目的：探讨注意缺陷多动障碍（ADHD）儿童脑体积测量的特点，以及合成和常规T1加权MRI（SyMRI和cT 1 w MRI）脑体积测量结果的一致性。研究方法：前瞻性收集了38例ADHD儿童患者和38例6-14岁健康儿童（HC）的脑SyMRI和cT 1 w图像。根据SyMRI数据自动估计灰质体积（GMV）、白色物质体积（WMV）、脑脊液（CSF）、非WM/GM/CSF（NoN）、髓鞘、髓鞘分数（MYF）、脑实质体积（BPV）和颅内体积（ICV），并从cT 1 w图像中提取四个匹配测量值（GMV、WMV、BPV、ICV）。采用协方差分析法对脑体积测量值进行组间差异分析。应用Pearson相关分析和组间相关系数（ICC）评价合成和cT 1 w MRI衍生测量值之间的相关性。结果如下：在脑体积测量中，ADHD组GMV、WMV、BPV较HC组明显降低，NON体积较HC组明显增加（p < 0.05），ICV、CSF、髓鞘体积和MYF无明显差异（p > 0.05）。关于从cT 1 w图像估计的GMV、WMV、BPV和ICV，ADHD和HC之间的组间差异与从SyMRI估计的结果一致。两种方法的相关系数分别为0.692，0.643，0.898，0.789，p < 0.001; ICC值分别为0.809，0.782，0.946，0.873。结论：我们的研究表明，ADHD儿童存在全脑发育障碍，但全脑髓鞘形成正常。此外，我们的研究结果表明，合成和CT 1 w MRI之间的儿童脑容量指数的高度一致性，这表明SyMRI在儿童脑容量分析中的高可靠性。
Objective: To investigate the profiles of brain volumetric measurements in children with attention deficit hyperactivity disorder (ADHD), and the consistency of these brain volumetric measurements derived from the synthetic and conventional T1 weighted MRI (SyMRI and cT1w MRI). Methods: Brain SyMRI and cT1w images were prospectively collected for 38 pediatric patients with ADHD and 38 healthy children (HC) with an age range of 6–14 years. The gray matter volume (GMV), white matter volume (WMV), cerebrospinal fluid (CSF), non-WM/GM/CSF (NoN), myelin, myelin fraction (MYF), brain parenchyma volume (BPV), and intracranial volume (ICV) were automatically estimated from SyMRI data, and the four matching measurements (GMV, WMV, BPV, ICV) were extracted from cT1w images. The group differences of brain volumetric measurements were performed, respectively, using analysis of covariance. Pearson correlation analysis and interclass correlation coefficient (ICC) were applied to evaluate the association between synthetic and cT1w MRI-derived measurements. Results: As for the brain volumetric measurements extracted from SyMRI, significantly decreased GMV, WMV, BPV, and increased NON volume (p < 0.05) were found in the ADHD group compared with HC; No group differences were found in ICV, CSF, myelin volume and MYF (p > 0.05). With regard to GMV, WMV, BPV, and ICV estimated from cT1w images, the group differences between ADHD and HC were consistent with the results estimated from SyMRI. And these four measurements showed noticeable correlation between the two approaches (r = 0.692, 0.643, 0.898, 0.789, respectively, p < 0.001; ICC values are 0.809, 0.782, 0.946, 0.873, respectively). Conclusion: Our study demonstrated a global brain development disability, but normal whole-brain myelination in children with ADHD. Moreover, our results demonstrated the high consistency of brain volumetric indices between synthetic and cT1w MRI in children, which indicates the high reliability of SyMRI in the child-brain volumetric analysis.
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作者：
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