Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii.
Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii.
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DOI：
10.1038/s41590-018-0250-8
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发表时间：
2019-01
影响因子：
30.5
通讯作者：
Yarovinsky F
中科院分区：
文献类型：
--
作者：
Safronova A;Araujo A;Camanzo ET;Moon TJ;Elliott MR;Beiting DP;Yarovinsky F
弓形虫是一种常见的原生动物寄生虫，感染了世界上三分之一的人口。值得注意的是，很少有人知道这种专性细胞内寄生虫的先天免疫感应机制。在这里，通过应用无偏的生物化学筛选方法，我们已经确定了人单核细胞识别T。通过检测alarmin S100 A11蛋白来检测弓形虫感染，该蛋白通过依赖于半胱天冬酶-1的机制从寄生虫感染的细胞中释放。S100 A11诱导T.弓形虫通过其受体介导，并通过诱导趋化因子CCL 2的表达来调节体内单核细胞的募集。我们的实验揭示了T.该方法基于检测感染介导的alarmin S100 A11释放和RAGE依赖的CCL 2诱导，CCL 2是宿主抵抗寄生虫所需的关键趋化因子。
Toxoplasma gondii is a common protozoan parasite that infects up to one-third of the world’s population. Notably, very little is known about innate immune-sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we have identified that human monocytes recognized the presence of T. gondii infection via detection of the alarmin S100A11 protein, which is released from parasite-infected cells via caspase-1-dependent mechanisms. S100A11 induced a potent chemokine response to T. gondii via engagement of its receptor RAGE and regulated monocyte recruitment in vivo by inducing expression of the chemokine CCL2. Our experiments have revealed a sensing system for T. gondii by human cells that is based on detection infection-mediated release of alarmin S100A11 and RAGE-dependent induction of CCL2, a crucial chemokine required for host resistance to the parasite.
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影响因子：
8.7
作者：
Man SM;Karki R;Kanneganti TD
通讯作者：
Kanneganti TD
影响因子：
8
作者：
López-Yglesias AH;Burger E;Araujo A;Martin AT;Yarovinsky F
通讯作者：
Yarovinsky F
影响因子：
30.3
作者：
Burger E;Araujo A;López-Yglesias A;Rajala MW;Geng L;Levine B;Hooper LV;Burstein E;Yarovinsky F
通讯作者：
Yarovinsky F
DOI：
10.1016/j.str.2010.05.017
发表时间：
2010-10-13
期刊：
Structure (London, England : 1993)
影响因子：
--
作者：
Koch M;Chitayat S;Dattilo BM;Schiefner A;Diez J;Chazin WJ;Fritz G
通讯作者：
Fritz G
影响因子：
9.6
作者：
Melo, Mariane B.;Jensen, Kirk D. C.;Saeij, Jeroen P. J.
通讯作者：
Saeij, Jeroen P. J.