High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.
High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.
复制标题
人类食管癌中 hst-1 和 int-2 基因共扩增的发生率很高。
作者：
T. Tsuda;E. Tahara;G. Kajiyama;H. Sakamoto;M. Terada;Takashi Sugimura
本文分析了36例食管鳞癌、42例胃腺癌和52例结直肠癌组织中hst-1和int-2基因的变化。Hst-1和int-2基因共扩增在36例食管癌中19例(52%)，34例原发癌组织中16例(47%)，10例转移瘤中10例(100%)。扩增程度从4倍到8倍不等。男性患者hst-1和int-2基因共扩增的发生率显著高于女性患者(P<0.05)。Hst-1和int-2基因共扩增有与临床分期相关的趋势。定位于11号染色体Q21-23带的孕激素受体基因在这些食道癌中未被扩增。Hst-1和int-2基因的共扩增似乎并不意味着11号染色体数目的增加，hst-1和int-2基因似乎在11号染色体Q13带的同一扩增单位。在胃癌和结直肠癌中未检测到hst-1和int-2基因的共扩增。提示hst-1和int-2基因在染色体上的扩增可能参与食管癌的发生、发展，尤其是转移。
We analyzed the alteration of the hst-1 and int-2 genes in 36 cases of esophageal squamous cell carcinoma, 42 cases of gastric adenocarcinoma, and 52 cases of colorectal adenocarcinoma. Coamplification of the hst-1 and int-2 genes was observed in 19 of 36 esophageal carcinomas (52%), 16 of 34 primary tumor tissues (47%), and 10 of 10 metastatic tumors (100%). The degree of amplification ranged from 4- to 8-fold. The incidence of hst-1 and int-2 gene coamplification was significantly higher in male patients than that in female patients (P less than 0.05). The coamplification of the hst-1 and int-2 genes had a tendency to correlate with clinical stage. The progesterone receptor gene, which is mapped to chromosome 11 at band q21-23, was not amplified in these esophageal carcinomas. Coamplification of the hst-1 and int-2 gene does not seem to imply increased numbers of chromosome 11, and the hst-1 and int-2 genes appear to be in same amplification unit on chromosome 11 at band q13. No coamplification of the hst-1 and int-2 genes was detected in gastric carcinomas and colorectal carcinomas. These results suggest that amplification of chromosomal locus of the hst-1 and int-2 genes might participate in carcinogenesis, in progression, and particularly in metastasis of esophageal carcinomas.
前列腺素（一种前列腺上皮细胞生长因子）的完整一级结构。
影响因子：
2.9
作者：
Crabb,JW;Armes,LG;Carr,SA;Johnson,CM;Roberts,GD;Bordoli,RS;McKeehan,WL
通讯作者：
McKeehan,WL
转染卡波西肉瘤 DNA 后重排的人类转化基因的分离。
DOI：
10.1073/pnas.84.16.5660
发表时间：
1987
影响因子：
11.1
作者：
DelliBovi,P;Basilico,C
通讯作者：
Basilico,C