Predicting changes in hemoglobin S after simple transfusion using complete blood counts.
Predicting changes in hemoglobin S after simple transfusion using complete blood counts.
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DOI：
10.1111/trf.14371
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发表时间：
2018-01
期刊：
影响因子：
2.9
通讯作者：
Knudson CM
中科院分区：
文献类型：
--
作者：
Mathur G;Ten Eyck P;Knudson CM
Hemoglobin S (HbS) percentages are used for management of patients with sickle cell disease (SCD). However, HbS measurements are often not routinely or rapidly performed. Rapid and accurate methods to estimate the HbS levels following simple transfusion may improve the care of SCD patients. A comprehensive review of the electronic medical record identified 24 stable SCD patients who had simple RBC transfusions and had HbS measurements before and after the transfusion that were less than 72 hours apart. Examination of these patients identified 62 separate transfusions that met our criteria. Three simple equations that utilized CBC values and readily available information from the medical record were used to predict the post transfusion HbS following transfusion. Equation 1: Predicted Post-HbS = Pre HbS X [Pre Hb/Post Hb]; Equation 2: Predicted Post-HbS = Pre HbS X [Pre Hematocrit (Hct)/Post Hct]; Equation 3: Predicted Post-HbS=Pre HbS X Total Pre Hb /[Total Pre Hb+ (RBC Vol x 20)]. The predicted HbS for all three equations showed a highly significant correlation with the measured post HbS value. R2 values for equations 1, 2 and 3 were 0.95, 0.92 and 0.97 respectively. Predicting the post-HbS values using an estimate of the patient’s total hemoglobin and the transfused hemoglobin (Equation 3) was the most precise. Reductions in HbS values in patients with SCD undergoing simple RBC transfusions can be reliably predicted using CBC measurements and simple arithmetic equations.
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影响因子：
158.5
作者：
Adams, RJ;McKie, VC;Wiznitzer, M
通讯作者：
Wiznitzer, M
影响因子：
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作者：
Kim, Jaehyup;Joseph, Ranjit;Sarode, Ravi
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Sarode, Ravi
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通讯作者：
Ford, Bradley A
影响因子：
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作者：
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Walker, RH
影响因子：
3.6
作者：
LINDERKAMP, O;VERSMOLD, HT;BETKE, K
通讯作者：
BETKE, K