Neural integration of satiation and food reward: role of GLP-1 and orexin pathways.
Neural integration of satiation and food reward: role of GLP-1 and orexin pathways.
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DOI：
10.1016/j.physbeh.2014.03.013
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发表时间：
2014-09
影响因子：
2.9
通讯作者：
Williams DL
中科院分区：
文献类型：
--
作者：
Williams DL
中枢神经系统对食物摄入的控制涉及检测、整合和响应各种内部和外部信号。为了维持能量稳态，大脑使用代谢状态的长期信号和与个别膳食的营养成分相关的短期信号。进食也明显受到享乐、奖励相关因素的影响：适口性、动机、习得性联想和预测食物可用性的线索。不同的神经回路已经被提出来调解这些稳态和享乐方面的饮食。这篇综述介绍了神经通路的研究，似乎都参与了，整合胃肠道饱食信号与食物奖励。首先，胰高血糖素样肽1的预测从孤束核的延髓核和腹侧被盖区进行了讨论作为一种机制，通过该机制，膳食相关的肠道信号可能会影响适口性，食物的动机，和膳食的大小。第二，食欲素从下丘脑外侧到孤束核和最后区的投射被讨论为一种机制，通过这种机制，预测奖励食物的线索可能会增加食物的动机，也抑制饱足感。其他潜在的整合位点和途径也进行了简要讨论。基于这些发现，我们认为参与能量稳态的脑回路和调节食物奖赏的脑回路实际上是重叠的，而且远没有以前认为的那么明显。
Central nervous system control of food intake involves detecting, integrating and responding to diverse internal and external signals. For maintenance of energy homeostasis, the brain uses long-term signals of metabolic status and short-term signals related to the nutrient content of individual meals. Feeding is also clearly influenced by hedonic, reward-related factors: palatability, motivation, and learned associations and cues that predict the availability of food. Different neural circuits have been proposed to mediate these homeostatic and hedonic aspects of eating. This review describes research on neural pathways that appear to be involved in both, integrating gastrointestinal satiation signaling with food reward. First, the glucagon-like peptide 1 projections from the nucleus of the solitary tract to the nucleus accumbens and ventral tegmental area are discussed as a mechanism through which meal-related gut signals may influence palatability, motivation for food, and meal size. Second, the orexin projection from lateral hypothalamus to the nucleus of the solitary tract and area postrema is discussed as a mechanism through which cues that predict rewarding food may act to increase motivation for food and also to suppress satiation. Additional potential integrative sites and pathways are also briefly discussed. Based on these findings, it is suggested that the brain circuitry involved in energy homeostasis and the circuitry mediating food reward are, in fact, overlapping and far less distinct than previously considered.
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影响因子：
2.9
作者：
Gaykema, Ronald P. A.;Daniels, Teresa E.;Shapiro, Nathan J.;Thacker, Gregory C.;Park, Su-Mi;Goehler, Lisa E.
通讯作者：
Goehler, Lisa E.
DOI：
10.1523/jneurosci.3262-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dossat AM;Lilly N;Kay K;Williams DL
通讯作者：
Williams DL
影响因子：
3.3
作者：
Choi, D. L.;Davis, J. F.;Magrisso, I. J.;Fitzgerald, M. E.;Lipton, J. W.;Benoit, S. C.
通讯作者：
Benoit, S. C.
影响因子：
4.8
作者：
Huo, Lihong;Maeng, Lisa;Grill, Harvey J.
通讯作者：
Grill, Harvey J.
DOI：
10.1152/ajpregu.00163.2004
发表时间：
2004-11-01
影响因子：
2.8
作者：
Grill, HJ;Carmody, JS;Kaplan, JM
通讯作者：
Kaplan, JM