Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression.
Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression.
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DOI：
10.3389/fonc.2020.619727
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发表时间：
2020
影响因子：
4.7
通讯作者：
Burgos PV
中科院分区：
文献类型：
--
作者：
Cerda-Troncoso C;Varas-Godoy M;Burgos PV
癌症进展涉及多种促肿瘤发生的生物学过程，包括细胞增殖、迁移、侵袭和存活。在这些促肿瘤发生过程中涉及的细胞途径是自噬，一种用于细胞质组分再循环以在应激条件下产生大分子结构单元和能量的分解代谢途径，以去除受损的细胞成分以适应不断变化的营养条件并维持细胞内稳态。在自噬过程中，细胞形成双膜隔离称为吞噬细胞的隔室，其成熟为自噬体。在与溶酶体融合后，货物在自体溶酶体内降解，并且所得大分子释放回细胞溶质中以供再利用。癌细胞在癌症进展过程中使用这种循环系统，但参与这种疾病的关键自噬参与者尚不清楚。累积的证据表明，自噬受体，选择性自噬的关键球员，在癌症进展过程中过表达，但这些受体调节促肿瘤发生的生物过程的机制仍然未知。在这篇综述中，我们总结了与自噬受体p62/SQSTM 1，NBR 1，NDP 52和OPTN在癌症进展中的促肿瘤发生作用相关的最重要的发现。此外，我们还发现了被这些受体降解的最相关的货物，这些受体已被证明是促肿瘤发生过程的关键调节剂。最后，我们讨论了自噬受体在这种疾病的细胞通路中的作用，如生长因子信号传导，氧化应激反应和细胞凋亡。总之，我们强调自噬受体应该被认为是癌症进展的重要参与者，这可以为开发新的诊断和癌症治疗策略提供一个利基。
Cancer progression involves a variety of pro-tumorigenic biological processes including cell proliferation, migration, invasion, and survival. A cellular pathway implicated in these pro-tumorigenic processes is autophagy, a catabolic route used for recycling of cytoplasmic components to generate macromolecular building blocks and energy, under stress conditions, to remove damaged cellular constituents to adapt to changing nutrient conditions and to maintain cellular homeostasis. During autophagy, cells form a double-membrane sequestering a compartment termed the phagophore, which matures into an autophagosome. Following fusion with the lysosome, the cargo is degraded inside the autolysosomes and the resulting macromolecules released back into the cytosol for reuse. Cancer cells use this recycling system during cancer progression, however the key autophagy players involved in this disease is unclear. Accumulative evidences show that autophagy receptors, crucial players for selective autophagy, are overexpressed during cancer progression, yet the mechanisms whereby pro-tumorigenic biological processes are modulated by these receptors remains unknown. In this review, we summarized the most important findings related with the pro-tumorigenic role of autophagy receptors p62/SQSTM1, NBR1, NDP52, and OPTN in cancer progression. In addition, we showed the most relevant cargos degraded by these receptors that have been shown to function as critical regulators of pro-tumorigenic processes. Finally, we discussed the role of autophagy receptors in the context of the cellular pathways implicated in this disease, such as growth factors signaling, oxidative stress response and apoptosis. In summary, we highlight that autophagy receptors should be considered important players of cancer progression, which could offer a niche for the development of novel diagnosis and cancer treatment strategies.
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维生素D受体信号传导和癌症。
DOI：
10.1016/j.ecl.2017.07.007
发表时间：
2017-12
影响因子：
4.5
作者：
Campbell MJ;Trump DL
通讯作者：
Trump DL
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影响因子：
7.8
作者：
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通讯作者：
Johansen, Terje
影响因子：
4.7
作者：
Fulda S
通讯作者：
Fulda S
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DOI：
10.26355/eurrev_201902_16992
发表时间：
2019-02-01
影响因子：
3.3
作者：
Dong, Y.;Wu, Y.;Yang, X. -D.
通讯作者：
Yang, X. -D.
影响因子：
3.3
作者：
Burke, P;Schooler, K;Wiley, HS
通讯作者：
Wiley, HS